1. GPCR/G Protein
    Metabolic Enzyme/Protease
  2. EBI2/GPR183
    Endogenous Metabolite
  3. 7α,25-Dihydroxycholesterol

7α,25-Dihydroxycholesterol (Synonyms: 7α,25-OHC)

Cat. No.: HY-113962 Purity: >99.0%
Handling Instructions

7α, 25-dihydroxycholesterol (7α,25-OHC) is a potent and selective agonist and endogenous ligand of the orphan GPCR receptor EBI2 (GPR183). 7α, 25-dihydroxycholesterol is highly potent at activating EBI2 (EC50=140 pM; Kd=450 pM). 7α, 25-dihydroxycholesterol can serve as a chemokine directing migration of B cells, T cells and dendritic cells.

For research use only. We do not sell to patients.

7α,25-Dihydroxycholesterol Chemical Structure

7α,25-Dihydroxycholesterol Chemical Structure

CAS No. : 64907-22-8

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10 mM * 1 mL in DMSO USD 626 In-stock
Estimated Time of Arrival: December 31
1 mg USD 225 In-stock
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5 mg USD 680 In-stock
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10 mg USD 1150 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

7α, 25-dihydroxycholesterol (7α,25-OHC) is a potent and selective agonist and endogenous ligand of the orphan GPCR receptor EBI2 (GPR183). 7α, 25-dihydroxycholesterol is highly potent at activating EBI2 (EC50=140 pM; Kd=450 pM). 7α, 25-dihydroxycholesterol can serve as a chemokine directing migration of B cells, T cells and dendritic cells[1][2].

IC50 & Target[1]

Human Endogenous Metabolite

 

In Vitro

In vitro, 7α, 25-dihydroxycholesterol (7α,25-OHC) stimulates the migration of EBI2-expressing mouse B and T cells with half-maximum effective concentration values around 500 pM, but had no effect on EBI2-deficient cells[1].

In Vivo

EBI2-deficient B cells or normal B cells desensitized by 7α,25-Dihydroxycholesterol (1 μM; 1.5 hours) pre-treatment shows reduced homing to follicular areas of the spleen[1].

Molecular Weight

418.65

Formula

C₂₇H₄₆O₃

CAS No.

64907-22-8

SMILES
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
References

Purity: >99.0%

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Keywords:

7α,25-Dihydroxycholesterol7α,25-OHCEBI2/GPR183Endogenous MetaboliteendogenousligandGPCRreceptorBcellsTimmuneresponsemigrationoxysterolsInhibitorinhibitorinhibit

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7α,25-Dihydroxycholesterol
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