2. GPCR/G Protein
  3. EBI2/GPR183
  4. NIBR189

NIBR189 

Cat. No.: HY-12336 Purity: 99.41%
COA Handling Instructions

NIBR189 is an EBI2 (Epstein-Barr virus-induced gene 2) antagonist. NIBR189 inhibits human and mouse EBI2 with IC50s of 11 and 16 nM, respectively. NIBR189 can be used for the research of autoimmune diseases.

For research use only. We do not sell to patients.

NIBR189 Chemical Structure

NIBR189 Chemical Structure

CAS No. : 1599432-08-2

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Solution
10 mM * 1 mL in DMSO USD 110 In-stock
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 110 In-stock
Solid
5 mg USD 100 In-stock
10 mg USD 170 In-stock
50 mg USD 550 In-stock
100 mg USD 880 In-stock
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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

NIBR189 Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE NIBR189

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

NIBR189 is an EBI2 (Epstein-Barr virus-induced gene 2) antagonist. NIBR189 inhibits human and mouse EBI2 with IC50s of 11 and 16 nM, respectively. NIBR189 can be used for the research of autoimmune diseases[1].

In Vitro

NIBR189 (0-1 μM; 3 h) blocks migration of U937 cells[1].
NIBR189 (0-10 μM) blocks oxysterol-dependent activation with an IC50 value of 9 nM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

NIBR189 Related Antibodies

Cell Migration Assay [1]

Cell Line: U937 cell lines
Concentration: 0-1 μM
Incubation Time: 3 hours
Result: Blocked the direct migration of U937 cells with an IC50 value of 0.3 nM.
In Vivo

1.19 Pharmacokinetic Properties of NIBR189 in Mice[1].

Mice
IV 1 mg/kg		 Mice
PO 3 mg/kg
CL (μL/min/mg) 16
t1/2 (h) 1.1
Vss (L/kg) 1.4
AUC (nmol·h/L) 2435 3608
Cmax (nmol/L) 835
tmax (h) 1
F (%) 49

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

429.31

Appearance

Solid

Formula

C21H21BrN2O3
CAS No.
SMILES

O=C(N1CCN(C(C2=CC=C(OC)C=C2)=O)CC1)/C=C/C3=CC=C(Br)C=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (116.47 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3293 mL 11.6466 mL 23.2932 mL
5 mM 0.4659 mL 2.3293 mL 4.6586 mL
10 mM 0.2329 mL 1.1647 mL 2.3293 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 2.5 mg/mL (5.82 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (5.82 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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NIBR189 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

NIBR1891599432-08-2NIBR 189NIBR-189EBI2/GPR183small moleculeG proteinautoimmune diseasesmigrationU937autoimmunemiceInhibitorinhibitorinhibit

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