1. GPCR/G Protein
  2. EBI2/GPR183

NIBR189 

Cat. No.: HY-12336 Purity: 99.24%
Handling Instructions

NIBR189 is a small molecule antagonist of the Epstein-Barr virus-induced gene 2 (EBI2; GPR183) receptor with IC50 of 16 nM(Binding) and 11 nM (Functional).

For research use only. We do not sell to patients.

NIBR189 Chemical Structure

NIBR189 Chemical Structure

CAS No. : 1599432-08-2

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 462 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
5 mg USD 420 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
10 mg USD 600 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
50 mg USD 1800 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
100 mg USD 2520 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

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  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

NIBR189 is a small molecule antagonist of the Epstein-Barr virus-induced gene 2 (EBI2; GPR183) receptor with IC50 of 16 nM(Binding) and 11 nM (Functional). IC50 value: 16/11 nM(Binding/Functional IC50) [1] Target: EBI2/GPR183 antagonist NIBR189 is a potent and selective EBI2 antagonist with improved pharmacokinetic properties which will help to probe the physiological function of EBI2 in health and disease.

References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 2.3293 mL 11.6466 mL 23.2932 mL
5 mM 0.4659 mL 2.3293 mL 4.6586 mL
10 mM 0.2329 mL 1.1647 mL 2.3293 mL
Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

429.31

Formula

C₂₁H₂₁BrN₂O₃

CAS No.

1599432-08-2

SMILES

O=C(N1CCN(C(C2=CC=C(OC)C=C2)=O)CC1)/C=C/C3=CC=C(Br)C=C3

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 47 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
NIBR189
Cat. No.:
HY-12336
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