2. Signaling Pathways
  3. GPCR/G Protein
  4. EBI2/GPR183
  5. EBI2/GPR183 Antagonist

EBI2/GPR183 Antagonist

EBI2/GPR183 Antagonists (4):

Cat. No. Product Name Effect Purity
  • HY-116814
    ML401
    		Antagonist 99.93%
    ML401, a potent chemical probe, selectively antagonizes EBI2 (also known as GPR183) with an IC50 of 1.03 nM. ML401 displays activity in a chemotaxis assay (IC50=6.24 nM). ML401 shows good stability and no toxicity.
  • HY-147222
    SAE-14
    		Antagonist 98.26%
    SAE-14 (compound SAE-14) is a potent, specific GPR183 antagonist with an IC50 value of 28.5 nM, can antagonize 7α, 25-OHC–induced calcium mobilization with IC50 value below 50 nM in HL-60 cells. GPR183 antagonist-1 can reverse allodynia in mice.
  • HY-162011
    GPR183 antagonist-2
    		Antagonist 99.96%
    GPR183 antagonist-2 (compound 32) is a selective GPR183 antagonist with good water solubility and excellent pharmacokinetic properties. GPR183 antagonist-2 significantly reduces paw and joint swelling and gene expression of pro-inflammatory cytokines (MCP-1, MMPs, and VEGF) in a collagen-induced arthritis (CIA) mouse model in a dose-dependent manner. GPR183 antagonist-2 can be used in the study of autoimmune diseases.
  • HY-157939
    GPR183 antagonist-3
    		Antagonist
    GPR183 antagonist-3 (compound 33) is an oral active GPR183 antagonist with the IC50 of 8.7 μM. GPR183 antagonist-3 displays strong in vitro antimigration and anti-inflammatory activity in monocytes, and improves the pathological symptoms of DSS-induced experimental colitis.