CCR2 - C-C motif chemokine receptor 2 Gene

Also Known as CKR2; CCR-2; CCR2A; CCR2B; CD192; CKR2A; CKR2B; CMKBR2; MCP-1-R; CC-CKR-2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 729230

About CCR2

Cytogenetic location: 3p21.31 Genomic coordinates (GRCh38): 3:46,354,111-46,360,940 (from NCBI)

This gene has 4 transcripts (splice variants), 151 orthologues and 23 paralogues. Biased expression in appendix (RPKM 15.2), lymph node (RPKM 5.1) and 12 other tissues.

Summary

The protein encoded by this gene is a receptor for monocyte chemoattractant protein-1, a chemokine which specifically mediates monocyte chemotaxis. Monocyte chemoattractant protein-1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. The encoded protein mediates agonist-dependent calcium mobilization and inhibition of adenylyl cyclase. This protein can also be a coreceptor with CD4 for HIV-1 Infection. This gene is located in the Chemokine Receptor gene cluster region of chromosome 3. [provided by RefSeq, Aug 2017]

CCR2 Products (2)

mRNA	Protein	Name
NM_001123396.4	NP_001116868.1	C-C chemokine receptor type 2 isoform B
NM_001123041.3	NP_001116513.2	C-C chemokine receptor type 2 isoform A

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables CCR2 chemokine receptor binding	IDA IDA: Inferred from direct assay	15995708	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	23938203	GOA

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within cytokine-mediated signaling pathway	IDA IDA: Inferred from direct assay	15995708	GOA
involved in positive regulation of astrocyte chemotaxis	IDA IDA: Inferred from direct assay	12271471	GOA
involved in positive regulation of monocyte chemotaxis	IDA IDA: Inferred from direct assay	18587271	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	15995708	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	15995708	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CCR2 Protein Structure

7tm_1

0
100
200
300
374 a.a.

Protein Preferred Names	Protein Names
C-C chemokine receptor type 2	MCP-1 receptor chemokine (C-C motif) receptor 2 monocyte chemoattractant protein 1 receptor monocyte chemotactic protein 1 receptor

CCR2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CCR2	P41597	POTEE	Homo sapiens	Q6S8J3	Anti Tag CoIP	33961781
Intra	CCR2	P41597	POTEE	Homo sapiens	Q6S8J3	Anti Tag CoIP	28514442

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CCR2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77589	CCR2b Protein-VLP, Human (HEK293)	P41597-2 (M1-L360)	≥ 95%, as determined by HPLC.
HY-P77590	CCR2b Protein-VLP, Human (Biotinylated, HEK293)	P41597-2 (M1-L360)	≥ 95%, as determined by HPLC.

CCR2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80385	CCR2 Antibody (YA548)	WB, IHC-P, IP, FC	Human, Mouse
HY-P84311	CCR2 Antibody (YA4008)	WB, FC, ELISA	Human
HY-P84311A	CCR2 Antibody (YA4008)(PBS only)	WB, FC, ELISA	Human

Related Diseases

Diseases	Alias
Burkitt Lymphoma	Burkitt'S Lymphoma BL Burkitt Lymphoma, Somatic Burkitt Lymphoma/Leukaemia Burkitt'S Tumor Burkitt'S Tumor Or Lymphoma Malignant Lymphoma, Burkitt'S Type Small Non-Cleaved Cell Lymphoma, Burkitt'S Type Small Non-Cleaved Cell Lymphoma Burkitt Tumor Burkitts Lymphoma Lymphoma, Small Noncleaved-Cell Burkitt Tumour Diffuse Small Noncleaved Malignant Burkitt Lymphoma Malignant Burkitt Lymphoma “Burkitt-Like” Lymphoma Undifferentiated Burkitt Lymphoma Small Noncleaved Cell Burkitt Lymphoma
Arthritis	Inflammatory Joint Disease Inflammatory Disorder Of Joint
Hypertension, Essential	Essential Hypertension Hypertension High Blood Pressure Hypertension, Essential, Susceptibility To Hypertensive Disease Primary Hypertension EHT Hypertension, Salt-Sensitive Essential, Susceptibility To Hyperpiesia Idiopathic Hypertension Hypertensive Disorder Hypertension, Essential, Susceptibility To, 3 Hypertension, Essential 3 Hypertension, Essential, Salt-Sensitive Hypertension, Essential, Susceptibility To, 6 Hypertension, Essential 6 Hypertension, Salt-Sensitive Essential Hypertension, Susceptibility To Hypertension, Essential, Susceptibility To, 4 Hypertension, Essential 4 Hypertension, Essential, Susceptibility To, 2 Hypertension, Essential 2 Hypertension, Essential, Susceptibility To, 1 Hypertension, Essential 1 Hypertension, Essential, Susceptibility To, 5 Hypertension, Essential 5 Htn Vascular Hypertensive Disorder Systemic Primary Arterial Hypertension Hbp - [High Blood Pressure] Systemic Arterial Hypertensive Disorder Elevated Blood Pressure Arterial Hypertension Nos Hypertension Nos Benign Hypertension Systemic Arterial Hypertension Systemic Hypertension Artery Htn Benign Htn Vascular Htn Vascular Hypertension Cholesterol Hypertension Cholesterol Htn Idiopathic Htn Malignant Hypertension Malignant Htn Raised Blood Pressure Cardiovascular Hypertension Primary Htn - [Hypertension] High Arterial Tension High Blood Pressure Disorder Ht - [Hypertension] Htn - [Hypertension] Hypertensive Vascular Disease Hypertensive Vascular Degeneration
Tenosynovial Giant Cell Tumor	Fibrous Histiocytoma Of Tendon Sheath Giant Cell Tumor Of Tendon Sheath Giant Cell Tumor Of Tenosynovium Giant Cell Tumour Of Tendon Sheath Giant Cell Tumour Of Tenosynovium Tenosynovial Giant Cell Tumour Diffuse-Type Gct Diffuse-Type Giant Cell Tumor Pigmented Villonodular Synovitis Tgct Tsgct
Cytomegalovirus Retinitis	Cmv Retinitis
Diabetes Mellitus	Diabetes
Type 2 Diabetes Mellitus	Insulin Resistance NIDDM Diabetes Mellitus, Non-Insulin-Dependent Type 2 Diabetes T2D Noninsulin-Dependent Diabetes Mellitus Diabetes Mellitus, Type Ii Maturity-Onset Diabetes Insulin Resistance, Severe, Digenic Diabetes Mellitus, Type 2 Diabetes Mellitus, Noninsulin-Dependent Diabetes Mellitus, Noninsulin-Dependent, Association With Diabetes Mellitus, Noninsulin-Dependent, Late Onset Hypertension, Insulin Resistance-Related, Susceptibility To Insulin Resistance, Susceptibility To Non-Insulin-Dependent Diabetes Mellitus Type Ii Diabetes Mellitus Adult-Onset Diabetes Mellitus Maturity-Onset Diabetes Mellitus Diabetes Mellitus Type 2 Type Ii Diabetes Type 2 Diabetes Mellitus, Susceptibility To Diabetes, Type 2 Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 2, Susceptibility To Diabetes Mellitus, Noninsulin-Dependent, 2 Diabetes Mellitus, Type Ii, Susceptibility To Hypertension, Insulin Resistance-Related Adult-Onset Diabetes Aodm Diabetes Mellitus, Adult-Onset Diabetes Mellitus Type Ii Diabetes Mellitus Type 2, Susceptibility To Diabetes, Type Ii, Susceptibility To Diabetes Type 2 Diabetes Mellitus Adult Onset Diabetes Maturity Onset Diabetes Nonketotic Diabetes Non-Insulin Dependent Diabetes Mellitus T2dm - [Type 2 Diabetes Mellitus] Niddm - [Non Insulin Dependent Diabetes Mellitus] Dm2 Dm Type Ii Diabetic Type 2 Insulin Requiring Type 2 Diabetes Noninsulin Dependent Diabetes Non-Insulin-Dependent Diabetes Mellitus Without Complications Diabetes Due To Insulin Secretory Defect Diabetes Mellitus Due To Insulin Secretory Defect Non-Insulin-Dependent Diabetes Of The Young Senile Diabetes Nonketotic Hyperglycaemia Stable Diabetes
Myocardial Infarction	Heart Attack Myocardial Infarction, Susceptibility To Myocardial Infarction 1 Myocardial Infarction, Protection Against Myocardial Infarction, Decreased Susceptibility To Myocardial Infarction, Decreased Myocardial Infarct MCI1 Premature Myocardial Infarction Myocardial Infarction, Susceptibility To, Type 1
Osteoporosis	Postmenopausal Osteoporosis Osteoporosis, Postmenopausal Bone Mineral Density Quantitative Trait Locus Bmnd Osteoporosis, Involutional Osteoporosis, Susceptibility To Osteoporosis, Postmenopausal, Susceptibility Bone Mineral Density Variation Qtl, Osteoporosis OSTEOP Involutional Osteoporosis Senile Osteoporosis Osteoporosis Postmenopausal Bone Mineral Density, Quantitative Trait Locus Osteoporosis, Senile Idiopathic Osteoporosis Bone Rarefaction Nos Type 1 Osteoporosis
Human Immunodeficiency Virus Type 1	Aids Hiv/Aids Aids, Delayed/Rapid Progression To Hiv-1, Susceptibility To Hiv-1 Viremia, Susceptibility To Human Immunodeficiency Virus Type 1, Susceptibility To Hiv-1 Aids, Slow Progression To Rapid Progression To Aids From Hiv1 Infection Hiv1 Infection, Resistance To Hiv1 Infection Hiv-1 Viremia Aids, Resistance To Aids, Rapid Progression To Hiv/Aids, Susceptibility To Hiv-1, Resistance To Hiv1, Resistance To Hiv1 Hiv-1 Disease, Delayed Progression Of Hiv-1 Disease, Rapid Progression Of Hiv Infection, Resistance To Hiv Type 1, Susceptibility To Hiv Type 1 Hiv-1 Infection Human Immunodeficiency Virus I Infection Acquired Immunodeficiency Syndrome Hiv-Infection/Aids
Acquired Immunodeficiency Syndrome	Acquired Immune Deficiency Syndrome AIDS Acquired Immune Deficiency Acquired Immunodeficiency Acquired Immunodeficiency Due To Protein Loss
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder
Inflammatory Bowel Disease	Inflammatory Bowel Diseases Bowel Disease, Inflammatory
Interstitial Lung Disease 2	Idiopathic Pulmonary Fibrosis Ipf Fibrocystic Pulmonary Dysplasia Pulmonary Fibrosis, Idiopathic Pulmonary Fibrosis, Idiopathic, Susceptibility To ILD2 Idiopathic Pulmonary Fibrosis, Familial Fibrosing Alveolitis, Cryptogenic Uip Cryptogenic Fibrosing Alveolitis Fibrosing Alveolitis Interstitial Pneumonitis, Usual Familial Idiopathic Pulmonary Fibrosis Idiopathic Fibrosing Alveolitis, Chronic Form Usual Interstitial Pneumonia Fibrosing Alveolitis Cryptogenic Hamman-Rich Disease Idiopathic Pulmonary Fibrosis Familial Interstitial Pneumonitis Usual Fibrosis Idiopathic Pulmonary Fibrosis, Pulmonary, Idiopathic Hamman-Rich Syndrome Chronic Idiopathic Pulmonary Fibrosis Acute Interstitial Pneumonia Interstitial Pulmonary Fibrosis Ipf - [Idiopathic Pulmonary Fibrosis] Idiopathic Lung Fibrosis Fibrosing Lung Disease Pulmonary Fibrosis Nos Fibrosing Pneumonitis
Systemic Lupus Erythematosus	Lupus Nephritis SLE Disseminated Lupus Erythematosus Systemic Lupus Erythematosus, Susceptibility To Lupus Erythematosus, Systemic Lupus Nephritis, Susceptibility To Libman-Sacks Disease Systemic Lupus Erythematosus Susceptibility To Sle - Lupus Erythematosus, Systemic Le Syndrome Lupus Lupus Erythematosus Systemic Lupus Erythematosus, Systemic, Susceptibility To Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus Systemic Lupus Erythematosus Nos Sle - [Systemic Lupus Erythematosus]
Rheumatoid Arthritis	RA Arthritis, Rheumatoid Rheumatoid Arthritis, Susceptibility To Arthritis Or Polyarthritis, Rheumatic Atrophic Arthritis Rheumatism Arthritis Rheumatoid Polyarthritis
Macrophage Activation Syndrome
Pneumoconiosis	Pneumoconioses Silicosis Nos Complicated Silicosis Fibrosis Of Lung With Silicosis Nodular Silicosis Pneumoconiosis Due To Silica Silicotic Fibrosis Of Lung Simple Silicosis Silicatosis Silicotic Lung Fibrosis Pneumoconiosis Due To Talc Pulmonary Talcosis Talc Lung Disease Talc Pneumoconiosis Talc Workers' Pneumoconiosis Talcosis Fibrosis Of Lung Due To Talc Asbestos Pneumoconiosis Amianthosis Asbestosis Lung Fibrosis With Asbestosis Pulmonary Asbestosis
Macular Degeneration, Age-Related, 1	Macular Degeneration Age-Related Macular Degeneration Macular Degeneration, Age-Related Age Related Macular Degeneration Age Related Macular Degeneration 1 ARMD1 Maculopathy, Age-Related, 1 Macular Degeneration, Age-Related, Reduced Risk Of Age Related Maculopathy 1 Age Related Maculopathies Age Related Maculopathy Senile Macular Degeneration Senile Macular Retinal Degeneration Macular Degeneration Of Retina Age-Related Maculopathy Amd Armd Age-Related Maculopathy, Susceptibility To Maculopathy Age-Related Macular Degeneration, Age-Related, 1, Susceptibility To Maculopathy, Age-Related Macular Degeneration, Age-Related, Type 1 Macular Degeneration, Age-Related, 2

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B1076	Medrysone	Activator	99.79%	Unkown
HY-117621A	PF-04634817 succinate	Antagonist	99.50%	Unkown
HY-117621	PF-04634817	Antagonist	98.87%	Unkown

Clinical Phase

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Phase
HY-14882	Cenicriviroc	Antagonist	99.51%	Phase 3
HY-13245	PF-4136309	Antagonist	99.86%	Phase 2
HY-109593	BMS-813160	Antagonist	99.93%	Phase 2
HY-101713	Ilacirnon	Inhibitor	98.05%	Phase 2
HY-50669	MK-0812	Antagonist	99.89%	Phase 2
HY-135891	AZD2423	Antagonist	99.91%	Phase 2
HY-13499	JNJ-41443532	Inhibitor	99.65%	Phase 2
HY-108432	BMS-741672	Antagonist	/	Phase 2
HY-129991	JNJ-17166864	Antagonist	/	Phase 2

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99781	Plozalizumab	Inhibitor	99.53%	Phase 2

Pre-clinical Phase

Bioactive Molecules (39)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15418	RS 504393	Antagonist	99.72%	Unkown
HY-50674	INCB3344	Antagonist	99.81%	Unkown
HY-13406	TAK-779	Antagonist	99.89%	Unkown
HY-18611A	Abaucin	Antagonist	99.59%	Unkown
HY-18611	Abaucin hydrochloride	Antagonist	99.94%	Unkown
HY-108323	CCR2 antagonist 4	Antagonist	99.89%	Unkown
HY-14882A	Cenicriviroc Mesylate	Antagonist	99.94%	Yes
HY-103355	YM022	Antagonist	99.87%	Unkown
HY-50081	CCR2-RA-[R]	Antagonist	99.21%	Unkown
HY-15450A	INCB 3284	Antagonist	99.30%	Unkown
HY-101908	BMS CCR2 22	Antagonist	99.27%	Unkown
HY-103362	CCR2 antagonist 4 hydrochloride	Antagonist	99.91%	Unkown
HY-50669A	MK-0812 Succinate	Antagonist	99.94%	Yes
HY-101264	CCR2 antagonist 3	Antagonist	99.91%	Unkown
HY-402739	CCR2-IN-1	Inhibitor	/	Unkown
HY-110132	JNJ-27141491	Antagonist	97.01%	Unkown
HY-112792	CCR2 antagonist 1	Antagonist	95.04%	Unkown
HY-P11553B	DOTA-ECL1i	Inhibitor	98.06%	Unkown
HY-50674A	INCB3344 R-isomer		98.01%	Unkown
HY-15450	INCB 3284 dimesylate	Antagonist	≥98.0%	Unkown
HY-186265	SD-24	Antagonist	/	Unkown
HY-180571	LUF7996	Degrader	/	Unkown
HY-136768	YJC-10592	Antagonist	/	Unkown
HY-171684	Anti-CCL2 (Carlumab)-MC-Vc-PAB-SN38	Antagonist	/	Unkown
HY-119658	PF-4178903	Antagonist	/	Unkown
HY-19009B	Propagermanium	Inhibitor	/	Unkown
HY-100819	RO5234444	Antagonist	/	Unkown
HY-P11553	ECL1i	Inhibitor	/	Unkown
HY-171685	Anti-CCL2 (Carlumab)-MC-Vc-PAB-DMEA-PEG2-Duocarmycin SA	Antagonist	/	Unkown
HY-181681	CXCR2 antagonist 10	Antagonist	/	Unkown
HY-171682	Anti-CCL2 (Carlumab)-McMMAF	Antagonist	/	Unkown
HY-180572	CCR2 ligand-1	Ligand	/	Unkown
HY-171681	Anti-CCL2 (Carlumab)-SPDB-DM4	Antagonist	/	Unkown
HY-171680	Anti-CCL2 (Carlumab)-SMCC-DM1	Antagonist	/	Unkown
HY-N17908	Viscumneoside V	Inhibitor	98.24%	Unkown
HY-179607	LUF8100	Antagonist	98.64%	Unkown
HY-50084	CCR2-RA	Antagonist	/	Unkown
HY-148100C	Emapticap pegol scramble negative control	Inhibitor	/	Unkown
HY-185299	CCR2 antagonist 6	Antagonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CCR2	MGD	MGI:106185
Canis familiaris	CCR2	VGNC	VGNC:57304
Bos taurus	CCR2	VGNC	VGNC:50025
Rattus norvegicus	CCR2	RGD	RGD:620876
Others	CCR2	NCBI