1. GPCR/G Protein
    Immunology/Inflammation
  2. CCR
  3. PF-04634817

PF-04634817 

Cat. No.: HY-117621 Purity: 98.87%
Handling Instructions

PF-0463481, an oral CCR2/5 dual antagonist, with a favorable ocular safety profile versus intravitreal therapies. PF-0463481 is safe and well-tolerated and being developed for the treatment of diabetic nephropathy.

For research use only. We do not sell to patients.

PF-04634817 Chemical Structure

PF-04634817 Chemical Structure

CAS No. : 1228111-63-4

Size Price Stock Quantity
1 mg USD 80 In-stock
Estimated Time of Arrival: December 31
5 mg USD 230 Get quote
10 mg   Get quote  
50 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

PF-0463481, an oral CCR2/5 dual antagonist, with a favorable ocular safety profile versus intravitreal therapies[1]. PF-0463481 is safe and well-tolerated and being developed for the treatment of diabetic nephropathy[2].

IC50 & Target[1]

CCR2

 

CCR5

 

Molecular Weight

511.58

Formula

C₂₅H₃₆F₃N₅O₃

CAS No.

1228111-63-4

SMILES

O=C(N1[[email protected]@]2([H])C[[email protected]@]([H])(C1)N(C3=NC=NC(C(F)(F)F)=C3)C2)[[email protected]@]4(C[[email protected]@H](CC4)N[[email protected]@H]5[[email protected]@H](COCC5)OC)C(C)C

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (97.74 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9547 mL 9.7736 mL 19.5473 mL
5 mM 0.3909 mL 1.9547 mL 3.9095 mL
10 mM 0.1955 mL 0.9774 mL 1.9547 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (4.89 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (4.89 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (4.89 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Product Name:
PF-04634817
Cat. No.:
HY-117621
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