1. GPCR/G Protein
    Immunology/Inflammation
  2. CCR
  3. AZD2423

AZD2423 

Cat. No.: HY-135891
Handling Instructions

AZD2423 is a potent, selective, orally bioavailable, and non-competitive CCR2 chemokine receptor negative allosteric modulator. AZD2423 has an IC50 of 1.2 nM for CCR2 Ca2+ flux .

For research use only. We do not sell to patients.

AZD2423 Chemical Structure

AZD2423 Chemical Structure

CAS No. : 1229603-37-5

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Description

AZD2423 is a potent, selective, orally bioavailable, and non-competitive CCR2 chemokine receptor negative allosteric modulator. AZD2423 has an IC50 of 1.2 nM for CCR2 Ca2+ flux [1][2][3].

IC50 & Target[1]

CCR2

 

In Vitro

AZD2423 inhibits MCP-1 induced calcium mobilization and chemotaxis of THP-1 cell line with an IC50 of 4 nM[1].

Molecular Weight

425.93

Formula

C₂₀H₂₉ClFN₅O₂

CAS No.

1229603-37-5

SMILES

O=C(N1CCN(C([[email protected]@H]2NCCN(C(C)(C)C)C2)=O)CC1)NC3=CC=C(Cl)C(F)=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

AZD2423AZD 2423AZD-2423CCRCC chemokine receptorchemokineoralmonocytechemotaxispainneuropathicInhibitorinhibitorinhibit

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