2. GPCR/G Protein Immunology/Inflammation
  3. CCR CXCR
  4. CXCR2 antagonist 10

CXCR2 antagonist 10 (Compound 10b) is a CCR2 antagonist with an IC50 of 0.48 μM. CXCR2 antagonist 10 also exhibits antagonistic activity against CXCR2/CCR7, with IC50 values of 4.18 μM and 2.07 μM, respectively. CXCR2 antagonist 10 is applicable for cancer research.

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CXCR2 antagonist 10

CXCR2 antagonist 10 Chemical Structure

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CXCR2 antagonist 10 Related Antibodies

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Description

CXCR2 antagonist 10 (Compound 10b) is a CCR2 antagonist with an IC50 of 0.48 μM. CXCR2 antagonist 10 also exhibits antagonistic activity against CXCR2/CCR7, with IC50 values of 4.18 μM and 2.07 μM, respectively. CXCR2 antagonist 10 is applicable for cancer research[1].

IC50 & Target[1]

CCR2

0.48 μM ()

CCR7

2.07 μM ()

CXCR2

4.18 μM ()

Parmacokinetics
Species Dose Route Cmax AUC0-last CL Vz T1/2 Tmax Bioavailability
Rat[1] 1 mg/kg i.v. 3154 ng/mL 3487 ng·h/mL 286 mL/h/kg 504 mL/kg 1.2 h / /
Rat[1] 1 mg/kg i.v. 3154 ng/mL 3487 ng·h/mL 286 mL/h/kg 504 mL/kg 1.2 h / /
Rat[1] 5 mg/kg i.g. 3920 ng/mL 28867 ng·h/mL / / 2.16 h 0.25 h 165 %
Rat[1] 5 mg/kg i.g. 3920 ng/mL 28867 ng·h/mL / / 2.16 h 0.25 h 165 %
Molecular Weight

384.38

Formula

C15H15F3N6OS
SMILES

OC[C@@H](C)NC1=NC(SCC2=CC=C(C(F)(F)F)C=C2)=NC3=C1N=NN3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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CXCR2 antagonist 10 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CXCR2 antagonist 10CCRCXCRCC chemokine receptorCXC chemokine receptorsC-X-C motif chemokine receptorsCCR7CCR2breast cancercolorectal cancerCXCR2non-small lung canceresophageal squamous cell cancergastric cancerprostate cancerhead and neck cancerInhibitorinhibitorinhibit

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CXCR2 antagonist 10
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