CXCR2 antagonist 10
CXCR2 antagonist 10 (Compound 10b) is a CCR2 antagonist with an IC50 of 0.48 μM. CXCR2 antagonist 10 also exhibits antagonistic activity against CXCR2/CCR7, with IC50 values of 4.18 μM and 2.07 μM, respectively. CXCR2 antagonist 10 is applicable for cancer research.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Fòrmula: C15H15F3N6OS
- Peso molecular:384.38
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
Descripciòn
IC50 & Target
[1]|
CCR2 0.48 μM () |
CCR7 2.07 μM () |
CXCR2 4.18 μM () |
Parmacokinetics
| Species | Dose | Route | Cmax | AUC0-last | CL | Vz | T1/2 | Tmax | Bioavailability |
|---|---|---|---|---|---|---|---|---|---|
| Rat[1] | 1 mg/kg | i.v. | 3154 ng/mL | 3487 ng·h/mL | 286 mL/h/kg | 504 mL/kg | 1.2 h | / | / |
| Rat[1] | 1 mg/kg | i.v. | 3154 ng/mL | 3487 ng·h/mL | 286 mL/h/kg | 504 mL/kg | 1.2 h | / | / |
| Rat[1] | 5 mg/kg | i.g. | 3920 ng/mL | 28867 ng·h/mL | / | / | 2.16 h | 0.25 h | 165 % |
| Rat[1] | 5 mg/kg | i.g. | 3920 ng/mL | 28867 ng·h/mL | / | / | 2.16 h | 0.25 h | 165 % |
Chemical Information
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Peso molecular 384.38
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Fòrmula C15H15F3N6OS
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SMILES
OC[C@@H](C)NC1=NC(SCC2=CC=C(C(F)(F)F)C=C2)=NC3=C1N=NN3
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CXCR2 antagonist 10 Related Classifications
HY-181681 Related Classifications
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