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Cat. No.: HY-181681

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CXCR2 antagonist 10

CXCR2 antagonist 10 (Compound 10b) is a CCR2 antagonist with an IC₅₀ of 0.48 μM. CXCR2 antagonist 10 also exhibits antagonistic activity against CXCR2/CCR7, with IC₅₀ values of 4.18 μM and 2.07 μM, respectively. CXCR2 antagonist 10 is applicable for cancer research.

For research use only. We do not sell to patients.

Formula: C₁₅H₁₅F₃N₆OS
Molecular Weight:384.38

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

CXCR2 antagonist 10 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Parmacokinetics
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

IC₅₀ & Target

^[1]

CCR2

0.48 μM ()

CCR7

2.07 μM ()

CXCR2

4.18 μM ()

All CCR Isoforms :

All CXCR Isoforms :

Parmacokinetics

Species	Dose	Route	C_max	AUC_0-last	CL	V_z	T_1/2	T_max	Bioavailability
Rat^[1]	1 mg/kg	i.v.	3154 ng/mL	3487 ng·h/mL	286 mL/h/kg	504 mL/kg	1.2 h	/	/
Rat^[1]	1 mg/kg	i.v.	3154 ng/mL	3487 ng·h/mL	286 mL/h/kg	504 mL/kg	1.2 h	/	/
Rat^[1]	5 mg/kg	i.g.	3920 ng/mL	28867 ng·h/mL	/	/	2.16 h	0.25 h	165 %
Rat^[1]	5 mg/kg	i.g.	3920 ng/mL	28867 ng·h/mL	/	/	2.16 h	0.25 h	165 %

Chemical Information

Molecular Weight 384.38
Formula C₁₅H₁₅F₃N₆OS
SMILES

OC[C@@H](C)NC1=NC(SCC2=CC=C(C(F)(F)F)C=C2)=NC3=C1N=NN3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Omanakuttan VK, et al. Synthesis, structure-activity relationship study and molecular modeling of triazolo [4, 5-d] pyrimidines targeting an intracellular allosteric binding site of various chemokine receptors. European Journal of Medicinal Chemistry. 2026 Jan 24:118597.

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight Molecular Weight

Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Keywords

MOQ

Minimum order quantity

100 mg

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