1. GPCR/G Protein
    Immunology/Inflammation
  2. CCR

CCR2 antagonist 1 

Cat. No.: HY-112792
Handling Instructions

CCR2 antagonist 1 is a high-affinity and long-residence-time CCR2 antagonist, with a Ki of 2.4 nM.

For research use only. We do not sell to patients.

CCR2 antagonist 1 Chemical Structure

CCR2 antagonist 1 Chemical Structure

CAS No. : 1683534-96-4

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  • Biological Activity

  • Technical Information

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  • References

Description

CCR2 antagonist 1 is a high-affinity and long-residence-time CCR2 antagonist, with a Ki of 2.4 nM.

IC50 & Target[1]

CCR2

2.4 nM (Ki)

In Vitro

The combination of SAR and SKR in the hit-to-lead process results in the discovery of a new higheaffinity and longeresidenceetime CCR2 antagonist (CCR2 antagonist 1 (compound 15a), Ki=2.4 nM; RT=714 min)[1].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8199 mL 9.0997 mL 18.1994 mL
5 mM 0.3640 mL 1.8199 mL 3.6399 mL
10 mM 0.1820 mL 0.9100 mL 1.8199 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

549.47

Formula

C₂₈H₃₂BrF₃N₂O

CAS No.

1683534-96-4

SMILES

O=C([[email protected]]1(C(C)C)C[[email protected]](N[[email protected]@H]2CCC3=C2C=CC(Br)=C3)CC1)N4CC5=C(C=CC(C(F)(F)F)=C5)CC4

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
CCR2 antagonist 1
Cat. No.:
HY-112792
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CCR2 antagonist 1

Cat. No.: HY-112792