2. GPCR/G Protein Immunology/Inflammation
  3. CCR
  4. (1S)-CCR2 antagonist 1

(1S)-CCR2 antagonist 1 is a left-handed chiral body of CCR2 antagonist 1 (HY-112792). CCR2 antagonist 1 is a high-affinity and long-residence-time CCR2 antagonist, with a Ki of 2.4 nM.

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(1S)-CCR2 antagonist 1 Chemical Structure

(1S)-CCR2 antagonist 1 Chemical Structure

CAS No. : 1683534-97-5

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Based on 1 publication(s) in Google Scholar

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(1S)-CCR2 antagonist 1 Related Antibodies

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Description

(1S)-CCR2 antagonist 1 is a left-handed chiral body of CCR2 antagonist 1 (HY-112792). CCR2 antagonist 1 is a high-affinity and long-residence-time CCR2 antagonist, with a Ki of 2.4 nM[1].

In Vitro

The combination of SAR and SKR in the hit-to-lead process results in the discovery of a new higheaffinity and longeresidenceetime CCR2 antagonist (CCR2 antagonist 1 (compound 15a), Ki=2.4 nM; RT=714 min)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(1S)-CCR2 antagonist 1 Related Antibodies
Molecular Weight

549.47

Formula

C28H32BrF3N2O
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C([C@]1(C(C)C)C[C@H](N[C@H]2CCC3=C2C=CC(Br)=C3)CC1)N4CC5=C(C=CC(C(F)(F)F)=C5)CC4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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(1S)-CCR2 antagonist 1 Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(1S)-CCR2 antagonist 11683534-97-5CCRCC chemokine receptorInhibitorinhibitorinhibit

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(1S)-CCR2 antagonist 1
Cat. No.:
HY-112792A
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