1. GPCR/G Protein Immunology/Inflammation
  2. CCR
  3. JNJ-27141491

JNJ-27141491 is a selective, noncompetitive and orally active functional antagonist of human CCR2.

For research use only. We do not sell to patients.

JNJ-27141491 Chemical Structure

JNJ-27141491 Chemical Structure

CAS No. : 871313-59-6

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  
Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Top Publications Citing Use of Products

View All CCR Isoform Specific Products:

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

JNJ-27141491 is a selective, noncompetitive and orally active functional antagonist of human CCR2[1].

IC50 & Target[1]

hCCR2

 

In Vitro

JNJ-27141491 inhibits MCP-1-induced [35S]GTPγS binding to hCCR2-CHO cell membranes (IC50=38±9 nM) and reduces MCP-1-induced Ca2+ mobilization in hCCR2-CHO cells (IC50=13±1 nM), in THP-1 cells (IC50=13±2 nM), and in human blood monocytes (IC50=43±4 nM). JNJ-27141491 also inhibits chemotaxis of human PBMC toward MCP-1, with an IC50 value of 97±16 nM[1].
JNJ-27141491 competes with the binding of MCP-1 to hCCR2 and acts as a noncompetitive antagonist of the CCR2 receptor[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

JNJ-27141491 (5-40 mg/kg; oral; once or twice daily) inhibits recruitment of monocytes and neutrophils into the alveolar air space of transgenic hCCR2 knockin mice[1].
JNJ-27141491 (20 mg/kg; oral; daily for 16 days) delays experimental autoimmune encephalomyelitis (EAE) in transgenic CCR2 mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Transgenic mCCR2 knockout/hCCR2 knockin C57BL/6 mice[1]
Dosage: 5, 10, 20, or 40 mg/kg
Administration: Oral, once or twice daily
Result: Once-daily oral treatment with 40, 20, 10, or 5 mg/kg inhibited the monocyte influx with 77, 57, 49, and 27%, respectively, compared with vehicle treatment, whereas this value was 74 and 22% after twice-daily oral treatment with 20 or 5 mg/kg. The neutrophil influx was also reduced; neutrophil numbers were decreased, with 56, 45, 20, and 8% after 40, 20, 10, or 5 mg/kg q.d. treatments and with 45 and 20% after 20 and 5 mg/kg b.i.d. treatments.
Molecular Weight

379.38

Formula

C17H15F2N3O3S

CAS No.
SMILES

CC[C@@H](C1=CC(F)=C(F)C=C1)N2C(C(OC)=O)=C(C3=CC=NO3)NC2=S

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

JNJ-27141491 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
JNJ-27141491
Cat. No.:
HY-110132
Quantity:
MCE Japan Authorized Agent: