CCR4 Protein-VLP, Human (HEK293, His)

CCR4 Protein-VLP, Human (HEK293, His) is recommended for animal immunization, ELISA. It is not recommended for receptor-ligand interaction detection and SPR/BLI assay since there are other irrelevant membrane proteins of the host on the VLP envelope, and the receptor-ligand interaction will have strong background interference. High requirements for chips and experimental protocols are needed for SPR/BLI assays. If VLP control is required, it is recommended HY-P701236. Tags can only be detected under denaturing conditions.

CCR4 Protein-VLP, a versatile entity, stands out as a high-affinity receptor for C-C type chemokines, specifically demonstrating binding affinity for CCL17/TARC, CCL22/MDC, and CKLF isoform 1/CKLF1. Its functional spectrum extends to the mediation of chemotactic responses through G(i) proteins, which activate a phosphatidylinositol-calcium second messenger system. Beyond its role as a chemoattractant homing receptor on circulating memory lymphocytes, CCR4 Protein-VLP also serves as a coreceptor for certain primary HIV-2 isolates. In the central nervous system (CNS), intriguingly, it has the potential to mediate hippocampal-neuron survival, adding a layer of complexity to its multifaceted functions.

Human

HEK293

C-10*His

P51679 (M1-L360)

1233  [NCBI]

Full Length

MNPTDIADTTLDESIYSNYYLYESIPKPCTKEGIKAFGELFLPPLYSLVFVFGLLGNSVVVLVLFKYKRLRSMTDVYLLNLAISDLLFVFSLPFWGYYAADQWVFGLGLCKMISWMYLVGFYSGIFFVMLMSIDRYLAIVHAVFSLRARTLTYGVITSLATWSVAVFASLPGFLFSTCYTERNHTYCKTKYSLNSTTWKVLSSLEINILGLVIPLGIMLFCYSMIIRTLQHCKNEKKNKAVKMIFAVVVLFLGFWTPYNIVLFLETLVELEVLQDCTFERYLDYAIQATETLAFVHCCLNPIIYFFLGEKFRKYILQLFKTCRGLFVLCQYCGLLQIYSADTPSSSYTQSTMDHDLHDAL

Purity analysis by SDS-PAGE is not available for VLP proteins.

<1 EU/μg, determined by LAL method.