CCR4 Protein-VLP, Human (HEK293, His)
CCR4 Protein-VLP, Human (HEK293, His) is recommended for animal immunization, ELISA. It is not recommended for receptor-ligand interaction detection and SPR/BLI assay since there are other irrelevant membrane proteins of the host on the VLP envelope, and the receptor-ligand interaction will have strong background interference. High requirements for chips and experimental protocols are needed for SPR/BLI assays. If VLP control is required, it is recommended HY-P701236. Tags can only be detected under denaturing conditions.
- Species: Human
- Source: HEK293
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
CCR4 Protein-VLP, Human (HEK293, His) is recommended for animal immunization, ELISA. It is not recommended for receptor-ligand interaction detection and SPR/BLI assay since there are other irrelevant membrane proteins of the host on the VLP envelope, and the receptor-ligand interaction will have strong background interference. High requirements for chips and experimental protocols are needed for SPR/BLI assays. If VLP control is required, it is recommended HY-P701236. Tags can only be detected under denaturing conditions.
Background
CCR4 Protein-VLP, a versatile entity, stands out as a high-affinity receptor for C-C type chemokines, specifically demonstrating binding affinity for CCL17/TARC, CCL22/MDC, and CKLF isoform 1/CKLF1. Its functional spectrum extends to the mediation of chemotactic responses through G(i) proteins, which activate a phosphatidylinositol-calcium second messenger system. Beyond its role as a chemoattractant homing receptor on circulating memory lymphocytes, CCR4 Protein-VLP also serves as a coreceptor for certain primary HIV-2 isolates. In the central nervous system (CNS), intriguingly, it has the potential to mediate hippocampal-neuron survival, adding a layer of complexity to its multifaceted functions.
Technical Parameters
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Species Human
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Source HEK293
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Tag C-10*His
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Accession
P51679 (M1-L360)
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Molecular Construction
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N-term
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CCR4-VLP (M1-L360)
Accession # P51679 -
10*His
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C-term
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Protein Length
Full Length
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Synonyms
CCR4; CKR4; C-C Motif Chemokine Receptor 4; C-C Chemokine Receptor Type 4; CC-CKR-4; C-C CKR-4; CMKBR4; CCR-4; K5-5; CDNA FLJ75821, Highly Similar To Homo Sapiens Chemokine (C-C Motif) Receptor 4 (CCR4), MRNA; Chemokine (C-C Motif) Receptor 4; Chemokine (
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AA Sequence
MNPTDIADTTLDESIYSNYYLYESIPKPCTKEGIKAFGELFLPPLYSLVFVFGLLGNSVVVLVLFKYKRLRSMTDVYLLNLAISDLLFVFSLPFWGYYAADQWVFGLGLCKMISWMYLVGFYSGIFFVMLMSIDRYLAIVHAVFSLRARTLTYGVITSLATWSVAVFASLPGFLFSTCYTERNHTYCKTKYSLNSTTWKVLSSLEINILGLVIPLGIMLFCYSMIIRTLQHCKNEKKNKAVKMIFAVVVLFLGFWTPYNIVLFLETLVELEVLQDCTFERYLDYAIQATETLAFVHCCLNPIIYFFLGEKFRKYILQLFKTCRGLFVLCQYCGLLQIYSADTPSSSYTQSTMDHDLHDAL
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Predicted Molecular Mass
43.2 kDa
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Glycosylation
Yes
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Purity
Purity analysis by SDS-PAGE is not available for VLP proteins.
Product Properties
Lyophilized powder.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US; may vary elsewhere.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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