L1CAM Protein, Human (HEK293, His)

The L1CAM protein is a neural cell adhesion molecule that plays a critical role in cell adhesion dynamics and initiation of tyrosine kinase receptor transmembrane signaling. Its importance spans brain development, affecting processes such as neuronal migration, axonal growth, fasciculations, and synaptogenesis. L1CAM Protein, Human (HEK293, His) is the recombinant human-derived L1CAM protein, expressed by HEK293 , with C-His labeled tag. The total length of L1CAM Protein, Human (HEK293, His) is 1101 a.a., with molecular weight of 160-200 kDa.

L1CAM, a neural cell adhesion molecule, intricately participates in the modulation of cell adhesion dynamics and the initiation of transmembrane signals at tyrosine kinase receptors. Its significance spans various stages of brain development, where it proves critical in processes such as neuronal migration, axonal growth, fasciculation, and synaptogenesis. In the mature brain, L1CAM continues to play a pivotal role in regulating the dynamics of neuronal structure and function, notably contributing to synaptic plasticity. This multifaceted protein interacts with SHTN1, with the interaction prominently occurring in axonal growth cones, and engages with isoform 2 of BSG, underscoring its involvement in diverse cellular functions.

Human

HEK293

C-His

P32004 (I20-E1120)

3897  [NCBI]

160-200 kDa

Greater than 90% as determined by reducing SDS-PAGE

Solution

Supplied as a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.