1. Immunology/Inflammation
  2. MyD88
  3. TLR1

TLR1 

Cat. No.: HY-W011400 Purity: >99.0%
Handling Instructions

TLR1 (compound 4a) is a low molecular weight, cell-penetrating Toll/IL-1 receptor/resistance (TIR) domain/BB-Loop mimic. TLR1 inhibits IL-1 receptor-mediated responses.

For research use only. We do not sell to patients.

TLR1 Chemical Structure

TLR1 Chemical Structure

CAS No. : 566914-00-9

Size Price Stock Quantity
500 μg (33 mM * 50  μL in Ethanol) USD 100 In-stock
Estimated Time of Arrival: December 31
1 mg (33 mM * 100  μL in Ethanol) USD 150 In-stock
Estimated Time of Arrival: December 31

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Based on 1 publication(s) in Google Scholar

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Description

TLR1 (compound 4a) is a low molecular weight, cell-penetrating Toll/IL-1 receptor/resistance (TIR) domain/BB-Loop mimic. TLR1 inhibits IL-1 receptor-mediated responses[1].

In Vitro

TLR1 inhibits IL-1β-induced phosphorylation of the mitogen-activated protein kinase p38 in EL4 thymoma cells and in freshly isolated murine lymphocytes in a concentration-dependent manner[1].

In Vivo

TLR1 interferes with the interactions between mouse MyD88 and IL-1RI at the TIR domains. TLR1 produces a significant attenuation of the IL-1β-induced fever response (200 mg/kg, i.p.)[1].

Molecular Weight

302.41

Formula

C₁₈H₂₆N₂O₂

CAS No.

566914-00-9

SMILES

O=C(N[[email protected]](C(N1CCCC1)=O)C(C)C)CCC2=CC=CC=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Pure form -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
References

Purity: >99.0%

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TLR1
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HY-W011400
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