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indica

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (4) Autophagy (1) Bacterial (4) CDK (1) Cholinesterase (ChE) (1) Dynamin (1) EBV (1) Endogenous Metabolite (1) Histone Acetyltransferase (1) HSP (1) iGluR (1) Influenza Virus (2) mGluR (1) Mitochondrial Metabolism (1) Monoamine Oxidase (1) MyD88 (1) NF-κB (1) Parasite (3) Phosphatase (1) PI3K (1) PKC (1) Toll-like Receptor (TLR) (1) Topoisomerase (1)
By Research Areas:	Cancer (5) Infection (8) Inflammation/Immunology (5) Metabolic Disease (3) Neurological Disease (4)
Click Chemistry:	Alkynes (1)

Inhibitors & Agonists

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Products

Click Chemistry

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N9898

Sinocrassoside C1

Others Others

Sinocrassoside C1 is a natural compound isolated from themethanolic extract of the whole plant ofSinocrassula indica (Crassulaceae) .
HY-N3787

Ducheside A

Others Others

Ducheside A is a ellagic glycoside that can be found in Ducheside indica Focke .
HY-122764

Acalyphin

Others Others

Acalyphin, a cyanogenic glucoside, is nature product that could be isolated from the aerial parts of Acalypha indica .

Sinocrassoside C1	Others	Others
Sinocrassoside C1 is a natural compound isolated from themethanolic extract of the whole plant ofSinocrassula indica (Crassulaceae) .

Ducheside A	Others	Others
Ducheside A is a ellagic glycoside that can be found in Ducheside indica Focke .

Acalyphin	Others	Others
Acalyphin, a cyanogenic glucoside, is nature product that could be isolated from the aerial parts of Acalypha indica .

HY-N12394

Norwogonin-8-O-glucuronide	Others	Inflammation/Immunology
Norwogonin-8-O-glucuronide is a glucuronide that can be isolated from Scutellaria indica. Norwogonin-8-O-glucuronide has anti-inflammatory activity .

HY-N12111

S-(-)-N-trans-Feruloyl normetanephrine	Others	Neurological Disease
S-(-)-N-trans-Feruloyl normetanephrine is a nature product with weak anti-acetylcholinesterase activity. S-(-)-N-trans-Feruloyl normetanephrine can be isolated from the aerial parts of Bassia indica Wight .

HY-107569

Garcinol 1 Publications Verification	Cholinesterase (ChE) Histone Acetyltransferase Apoptosis Endogenous Metabolite	Inflammation/Immunology Cancer
Garcinol, a polyisoprenylated benzophenone harvested from Garcinia indica, exerts anti-cholinesterase properties towards acetyl cholinesterase (AChE) and butyrylcholinesterase (BChE) with IC₅₀s of 0.66 µM and 7.39 µM, respectively . Garcinol also inhibits histone acetyltransferases (HATs, IC₅₀= 7 μM) and p300/CPB-associated factor (PCAF, IC₅₀ = 5 μM). Garcinol has anti-inflammatory and anti-cancer activity .

HY-N2471

Aristolindiquinone

Others Others

Aristolindiquinone can be isolated from Aristolwhia indica .
HY-121731

Nimbocinone

Others Metabolic Disease

Nimbocinone, isolated from Azadirachta indica, exhibits antidiabetogenic activity .
HY-N3171A

(+)-Nortrachelogenin

Wikstromol
Apoptosis PI3K Cancer

(+)-Nortrachelogenin (Wikstromol), a pharmacologically ligand from from wikstroemia indica, possesses antileukemic activity .

Aristolindiquinone	Others	Others
Aristolindiquinone can be isolated from Aristolwhia indica .

Nimbocinone	Others	Metabolic Disease
Nimbocinone, isolated from Azadirachta indica, exhibits antidiabetogenic activity .

(+)-Nortrachelogenin Wikstromol	Apoptosis PI3K	Cancer
(+)-Nortrachelogenin (Wikstromol), a pharmacologically ligand from from wikstroemia indica, possesses antileukemic activity .

HY-E70114

exo-Polygalacturonase	Others	Others
exo-Polygalacturonase is an extracellular pectinolytic enzyme. exo-Polygalacturonase acts from the non-reducing side, hydrolyzes pectic acids, and releases mono-galacturonate .

HY-N1465

Aristolochic acid D

Aristolochic acid D is an aristolochic acid derivative isolated from stems of Aristolochia indica. Aristolochic acid is nephrotoxin and carcinogen .
HY-N7005

Clitorin

Others Metabolic Disease

Clitorin is a kaempferol glycoside isolated from the flowers and leaves of Acalypha indica, and has antioxidant activity .
HY-N5038

Mauritianin

Topoisomerase Cancer

Mauritianin is a kaempferol glycoside isolated from the flowers and leaves of Acalypha indica. Mauritianin is a topoisomerase I inhibitor .

Aristolochic acid D
Aristolochic acid D is an aristolochic acid derivative isolated from stems of Aristolochia indica. Aristolochic acid is nephrotoxin and carcinogen .

Clitorin	Others	Metabolic Disease
Clitorin is a kaempferol glycoside isolated from the flowers and leaves of Acalypha indica, and has antioxidant activity .

Mauritianin	Topoisomerase	Cancer
Mauritianin is a kaempferol glycoside isolated from the flowers and leaves of Acalypha indica. Mauritianin is a topoisomerase I inhibitor .

HY-N9615

Azadiradione	HSP	Infection Neurological Disease Inflammation/Immunology
Azadiradione is a bioactive limonoid found in Azadirachta indica. Azadiradione is a HSF1 activator. Azadiradione has antimycobacterial, anti-nociceptive and anti-inflammatory activities .

HY-N3694

Deacetylnimbin Desacetyl nimbin	Others	Others
Deacetylnimbin is a limonoid isolated from Azadirachta indica. Deacetylnimbin can be used as a plant metabolite, a food repellent and as a growth regulator for insects such as S. litura, P. ricini and O. fscovittata .

HY-123026

Salannin	Bacterial	Infection
Salannin, a limonoid bitter principle of the seed oil of Azadirachta indica, shows antiulcer and spermicidal activities. Salannin displays antibacterial activity towards both Gram-positive and Gram-negative bacteria .

HY-N9540

Methyl citrate	Monoamine Oxidase	Neurological Disease
Methyl citrate is a Monoamine oxidase B (MAO-B) inhibitor (IC₅₀=0.23 mM). Methyl citrate is isolated from the fruits of Opuntia ficus-indica var. saboten Makino .

HY-163450

Nimbiol

Bacterial Infection

Nimbiol exhibits binding energy for FtsZ and shows potential anti-FtsZ effect .

Nimbiol	Bacterial	Infection
Nimbiol exhibits binding energy for FtsZ and shows potential anti-FtsZ effect .

HY-N0703

Schaftoside 3 Publications Verification	Toll-like Receptor (TLR) MyD88 Dynamin Mitochondrial Metabolism Autophagy	Inflammation/Immunology
Schaftoside is a flavonoid found in a variety of Chinese herbal medicines, such as Eleusine indica. Schaftoside inhibits the expression of TLR4 and Myd88. Schaftoside also decreases Drp1 expression and phosphorylation, and reduces mitochondrial fission .

HY-N0699

Daphnoretin 1 Publications Verification Dephnoretin; Thymelol	PKC Influenza Virus	Infection
Daphnoretin (Dephnoretin), isolated from Wikstroemia indica, possesses antiviral activity . Daphnoretin likes PMA, may direct activation of protein kinase C which in turn activated NADPH oxidase and elicited respiratory burst .

HY-N2876

Anisofolin A	Parasite Bacterial	Infection
Anisofolin A is a flavonoid that can be isolated from Anisomeles indica. Anisofolin A has antimalarial activity (IC₅₀: 4.39 μM), and antimycobacterium activity (IC₅₀: 4.50 μM) against M. tuberculosis H37Ra .

HY-12597

Quisqualic acid L-Quisqualic acid	iGluR mGluR	Neurological Disease
Quisqualic acid (L-Quisqualic acid), a natural analog of glutamate, is a potent and pan two subsets (iGluR and mGluR) of excitatory amino acid (EAA) agonist with an EC₅₀ of 45 nM and a K_i of 10 nM for mGluR1R. Quisqualic acid is isolated from the fruits of Quisqualis indica .

HY-N1710

28-Deoxonimbolide
28-Deoxonimbolide is a nimbin (HY-N3187) type limonoid, that can be isolated from Azadirachta indica seed extracts. 28-Deoxonimbolide shows anticancer activity. 28-Deoxonimbolide induces apoptotic cell death in HL60 cells via both the mitochondrial- and the death receptor-mediated pathways .

HY-133108

Azadirachtin B	EBV Parasite Phosphatase Influenza Virus	Infection Metabolic Disease Inflammation/Immunology Cancer
Azadirachtin B is an limonoid isolated from seed kernels of Azadirachta indica. Azadirachtin B increases alkaline phosphatase (ALP) activity and stimulates osteoblast differentiation. Azadirachtin B is active against the Epstein-Barr virus early antigen (EBV-EA). Azadirachtin B has insecticidal, nematocidal, anticancer, anti-inflammatory, antiviral and osteogenic properties .

HY-N2939

Bis-5,5-Nortrachelogenin	Others	Others
Bis-5,5-Nortrachelogenin is isolated from active extract of root of Wikstroemia indica. Bis-5,5-Nortrachelogenin inhibits nitric oxide (NO) production in a lipopolysaccharide (LPS) and recombinant mouse interferon-γ(IFN-γ) activated murine macrophage-like cell line, RAW 264.7 with an IC₅₀ value of 48.6 mM .

HY-N1654

2',3'-Dehydrosalannol	Bacterial	Infection
2',3'-Dehydrosalannol is a potent antibacterial agent. 2',3'-Dehydrosalannol shows antibacterial activity against K. pneumonia ATCC 13883, P. aeruginosa ATCC 27853, S. aureus ATCC 25922, E. coli ATCC 11775, and E. faecalis ATCC 10541, with MIC values of 0.78, 1.56, 1.56, 6.25, and 25 µg/mL, respectively .

HY-116035

Nimbolide 1 Publications Verification	NF-κB CDK Apoptosis	Cancer
Nimbolide is a triterpene compound that can be isolated from neem (Azadirachta indica), possesses anticancer and antiproliferative activity. Nimbolide induces tumor cell apoptosis by inhibiting NF-κB and CDK4/CDK6 kinase. Nimbolide suppresses the Wnt, PI3K-Akt, MAPK and JAK-STAT signaling pathways .

HY-N10096

Epoxyazadiradione	Parasite	Infection
Epoxyazadiradione is a limonoid purified from neem (Azadirachta indica) fruits. Epoxyazadiradione inhibits the tautomerase activity of MIF of both human (huMIF) and malaria parasites (Plasmodium falciparum (PfMIF) and Plasmodium yoelii (PyMIF)) non-competitively in a reversible fashion (K_i, 2.11-5.23 μM). Epoxyazadiradione has the potential against proinflammatory reactions induced by MIF of both malaria parasites and human .

HY-Y0585

D-(-)-Mandelic acid 1 Publications Verification (R)-(-)-Mandelic acid
D-(-)-Mandelic acid is the isomer of Mandelic acid (HY-W015591). Mandelic acid is an orally active α hydroxycarboxylic acid that can be isolated from bitter almonds and Aesculus indica. Mandelic acid has anti-oxidant and anti-inflammatory activities. Mandelic acid reduces the liberation of auto-antigens, oxygen free radicals and proinflammatory mediators resulting in inhibition of protein denaturation, which is favorable in dismissing the pain related with arthritis .

HY-N10091

2,3-Dihydro-3α-methoxynimbolide	Apoptosis	Others
2,3-Dihydro-3α-methoxynimbolide is a limonoid compound isolated from the extracts of bark, leaves, roots, and seeds of Azadirachta indica A. Juss. var. siamensis Valeton. 2,3-Dihydro-3α-methoxynimbolide exhibits potent cyto-toxicities against one or more cell lines. 2,3-Dihydro-3α-methoxynimbolide activates caspases-3, -8, and -9, while increases the ratio of Bax/Bcl-2. 2,3-Dihydro-3α-methoxynimbolide induces apoptosis via both mitochondrial and death receptor pathways in AZ521 .

Sinocrassoside C1	Structural Classification Sinocrassula indica (Decne.) Berger Flavonoids Flavones Source classification Crassulaceae Plants Saccharides Monosaccharides	Others
Sinocrassoside C1 is a natural compound isolated from themethanolic extract of the whole plant ofSinocrassula indica (Crassulaceae) .

Ducheside A	Structural Classification Natural Products Phyllanthaceae Source classification Bridelia ferruginea Benth. Plants	Others
Ducheside A is a ellagic glycoside that can be found in Ducheside indica Focke .

Acalyphin	Structural Classification Gramineae Source classification Plants Oryza sativa subsp. indica Kato Saccharides	Others
Acalyphin, a cyanogenic glucoside, is nature product that could be isolated from the aerial parts of Acalypha indica .

Norwogonin-8-O-glucuronide	Structural Classification Scutellaria indica L. Flavonoids Flavones Labiatae Source classification Plants	Others
Norwogonin-8-O-glucuronide is a glucuronide that can be isolated from Scutellaria indica. Norwogonin-8-O-glucuronide has anti-inflammatory activity .

S-(-)-N-trans-Feruloyl normetanephrine	Structural Classification Source classification Bassia indica (Wight) A.J.Scott Phenols Polyphenols Amaranthaceae Plants	Others
S-(-)-N-trans-Feruloyl normetanephrine is a nature product with weak anti-acetylcholinesterase activity. S-(-)-N-trans-Feruloyl normetanephrine can be isolated from the aerial parts of Bassia indica Wight .

Garcinol 1 Publications Verification	Structural Classification Classification of Application Fields Guttiferae Phenols Polyphenols Plants Inflammation/Immunology Disease Research Fields Garcinia indica	Cholinesterase (ChE) Histone Acetyltransferase Apoptosis Endogenous Metabolite
Garcinol, a polyisoprenylated benzophenone harvested from Garcinia indica, exerts anti-cholinesterase properties towards acetyl cholinesterase (AChE) and butyrylcholinesterase (BChE) with IC₅₀s of 0.66 µM and 7.39 µM, respectively . Garcinol also inhibits histone acetyltransferases (HATs, IC₅₀= 7 μM) and p300/CPB-associated factor (PCAF, IC₅₀ = 5 μM). Garcinol has anti-inflammatory and anti-cancer activity .

Aristolindiquinone	Quinones Structural Classification Source classification Aristolochia indica L. Plants Naphthalene Quinones Aristolochiaceae	Others
Aristolindiquinone can be isolated from Aristolwhia indica .

Nimbocinone	Triterpenes Structural Classification Terpenoids Source classification Plants Azadirachta indica A. Juss. Meliaceae	Others
Nimbocinone, isolated from Azadirachta indica, exhibits antidiabetogenic activity .

(+)-Nortrachelogenin Wikstromol	Structural Classification Natural Products Classification of Application Fields Thymelaeaceae Source classification Phenols Polyphenols Plants Disease Research Fields Cancer Wikstroemia indica	Apoptosis PI3K
(+)-Nortrachelogenin (Wikstromol), a pharmacologically ligand from from wikstroemia indica, possesses antileukemic activity .

Clitorin	Flavonols Flavonoids other families Classification of Application Fields Source classification Phenols Polyphenols Metabolic Disease Plants Disease Research Fields	Others
Clitorin is a kaempferol glycoside isolated from the flowers and leaves of Acalypha indica, and has antioxidant activity .

Mauritianin	Flavonols Classification of Application Fields Source classification Erythrina stricta Roxb. Plants Compositae Acalypha indica Linn. Flavonoids Phenols Polyphenols Euphorbiaceae Disease Research Fields Cancer	Topoisomerase
Mauritianin is a kaempferol glycoside isolated from the flowers and leaves of Acalypha indica. Mauritianin is a topoisomerase I inhibitor .

Azadiradione	Triterpenes other families Neurological Disease Classification of Application Fields Terpenoids Source classification Plants Inflammation/Immunology Disease Research Fields Biological Pesticide Research Agricultural Research	HSP
Azadiradione is a bioactive limonoid found in Azadirachta indica. Azadiradione is a HSF1 activator. Azadiradione has antimycobacterial, anti-nociceptive and anti-inflammatory activities .

Deacetylnimbin Desacetyl nimbin	Triterpenes Structural Classification Terpenoids Source classification Plants Azadirachta indica A. Juss. Meliaceae	Others
Deacetylnimbin is a limonoid isolated from Azadirachta indica. Deacetylnimbin can be used as a plant metabolite, a food repellent and as a growth regulator for insects such as S. litura, P. ricini and O. fscovittata .

Salannin	Infection Triterpenes Structural Classification other families Classification of Application Fields Terpenoids Source classification Plants Disease Research Fields	Bacterial
Salannin, a limonoid bitter principle of the seed oil of Azadirachta indica, shows antiulcer and spermicidal activities. Salannin displays antibacterial activity towards both Gram-positive and Gram-negative bacteria .

Methyl citrate	Cactaceae Ketones, Aldehydes, Acids Source classification Opuntia ficus-indica (L.) Mill. Plants	Monoamine Oxidase
Methyl citrate is a Monoamine oxidase B (MAO-B) inhibitor (IC₅₀=0.23 mM). Methyl citrate is isolated from the fruits of Opuntia ficus-indica var. saboten Makino .

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indica

Inhibitors & Agonists

NaturalProducts

Click Chemistry

Natural
Products