1. Neuronal Signaling
    Metabolic Enzyme/Protease
  2. AChE
    Endogenous Metabolite
  3. sn-Glycero-3-phosphocholine

sn-Glycero-3-phosphocholine (Synonyms: Choline Alfoscerate; Alpha-GPC; L-α-GPC)

Cat. No.: HY-17552 Purity: >98.0%
Handling Instructions

sn-Glycero-3-phosphocholine (Choline Alfoscerate) is a precursor in the biosynthesis of brain phospholipids and increases the bioavailability of choline in nervous tissue. sn-Glycero-3-phosphocholine (Choline Alfoscerate) has significant effects on cognitive function with a good safety profile and tolerability, and is effective in the treatment of Alzheimer's disease and dementia.

For research use only. We do not sell to patients.

sn-Glycero-3-phosphocholine Chemical Structure

sn-Glycero-3-phosphocholine Chemical Structure

CAS No. : 28319-77-9

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Based on 1 publication(s) in Google Scholar

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Description

sn-Glycero-3-phosphocholine (Choline Alfoscerate) is a precursor in the biosynthesis of brain phospholipids and increases the bioavailability of choline in nervous tissue. sn-Glycero-3-phosphocholine (Choline Alfoscerate) has significant effects on cognitive function with a good safety profile and tolerability, and is effective in the treatment of Alzheimer's disease and dementia[1][2].

IC50 & Target

Human Endogenous Metabolite

 

In Vivo

Treatment with sn-Glycero-3-phosphocholine (Choline Alfoscerate) (250 mg/kg; i.m.; daily for 3 weeks) after seizure can improve seizure-induced cognitive impairment[2].
sn-Glycero-3-phosphocholine (Choline Alfoscerate) increases the release of acetylcholine in rat hippocampus, facilitates learning and memory in experimental animals, improves brain transduction mechanisms and decreases age-dependent structural changes occurring in rat brain areas involved in learning and memory[3].

Animal Model: Sprague-Dawley male rats[2]
Dosage: 250 mg/kg
Administration: Intramuscular injection; starting at 3 weeks after seizure and continuing daily for 3 weeks
Result: Improve seizure-induced cognitive impairment.
Clinical Trial
Molecular Weight

257.22

Formula

C₈H₂₀NO₆P

CAS No.

28319-77-9

SMILES

O=P(OCC[N+](C)(C)C)(OC[[email protected]](O)CO)[O-]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

H2O : 500 mg/mL (1943.86 mM; Need ultrasonic)

DMSO : ≥ 125 mg/mL (485.97 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.8877 mL 19.4386 mL 38.8772 mL
5 mM 0.7775 mL 3.8877 mL 7.7754 mL
10 mM 0.3888 mL 1.9439 mL 3.8877 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (8.09 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (8.09 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (8.09 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: >98.0%

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Keywords:

sn-Glycero-3-phosphocholineCholine AlfoscerateAlpha-GPCL-α-GPCAChEEndogenous MetaboliteAcetylcholinesteraseInhibitorinhibitorinhibit

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Product name:
sn-Glycero-3-phosphocholine
Cat. No.:
HY-17552
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