sn-Glycero-3-phosphocholine-d₉ (Synonyms: Choline Alfoscerate-d₉; Alpha-GPC-d₉; L-α-GPC-d₉)

Cat. No.: HY-17552S: Ficha de datos
COA

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Instrucciones de manejo
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sn-Glycero-3-phosphocholine-d₉ is the deuterium labeled sn-Glycero-3-phosphocholine. sn-Glycero-3-phosphocholine (Choline Alfoscerate) is a precursor in the biosynthesis of brain phospholipids and increases the bioavailability of choline in nervous tissue. sn-Glycero-3-phosphocholine (Choline Alfoscerate) has significant effects on cognitive function with a good safety profile and tolerability, and is effective in the treatment of Alzheimer's disease and dementia.

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sn-Glycero-3-phosphocholine-d<sub>9</sub>

sn-Glycero-3-phosphocholine-d₉ Estructura química

No. CAS : 2260669-07-4

Tamaño	Precio	Stock
1 mg		Pide un presupuesto y un plazo de entrega

* Seleccione Cantidad antes de agregar artículos.

This product is a controlled substance and not for sale in your territory.

Other Forms of sn-Glycero-3-phosphocholine-d₉:

sn-Glycero-3-phosphocholine In-stock

Recomendaciones destacadas

•Related Small Molecules:

•Related Proteins:

Ver todos los productos específicos de isoformas Cholinesterase (ChE):

Ver todas las isoformas

AChE BChE

Ver todos los productos específicos de isoformas Endogenous Metabolite:

Ver todas las isoformas

Human Endogenous Metabolite Microbial Metabolite

Actividad biológica
Pureza y Documentación
Referencias
Revisión del cliente

Descripciòn

Application

1. This compound can be used as a tracer.
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Peso molecular

266.28

Fòrmula

C₈H₁₁D₉NO₆P

No. CAS

2260669-07-4

Unlabeled CAS

28319-77-9

Appearance

Oil

Color

Colorless to light yellow

SMILES

O=P(OCC[N+](C([2H])([2H])[2H])(C([2H])([2H])[2H])C([2H])([2H])[2H])(OC[C@H](O)CO)[O-]

Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvente y solubilidad

In Vitro:

H₂O : 100 mg/mL (375.54 mM; Need ultrasonic and warming)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.7554 mL	18.7772 mL	37.5545 mL
5 mM	0.7511 mL	3.7554 mL	7.5109 mL
10 mM	0.3755 mL	1.8777 mL	3.7554 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Calculadora de molaridad
Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Pureza y Documentación

Purity: 99.64%

Select Batch:

Ficha de datos (273 KB) SDS (252 KB)

COA (249 KB) Elemental Analysis Report (107 KB)

Instrucciones de manejo (2659 KB)

Referencias

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Lee SH, et al. Late treatment with choline alfoscerate (l-alpha glycerylphosphorylcholine, α-GPC) increases hippocampal neurogenesis and provides protection against seizure-induced neuronal death and cognitive impairment. Brain Res. 2017 Jan 1;1654(Pt A):66-76. [Content Brief]

[3]. Traini E, et al. Choline alphoscerate (alpha-glyceryl-phosphoryl-choline) an old choline- containing phospholipidwith a still interesting profile as cognition enhancing agent. Curr Alzheimer Res. 2013 Dec;10(10):1070-9. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	3.7554 mL	18.7772 mL	37.5545 mL	93.8861 mL
	5 mM	0.7511 mL	3.7554 mL	7.5109 mL	18.7772 mL
	10 mM	0.3755 mL	1.8777 mL	3.7554 mL	9.3886 mL
	15 mM	0.2504 mL	1.2518 mL	2.5036 mL	6.2591 mL
	20 mM	0.1878 mL	0.9389 mL	1.8777 mL	4.6943 mL
	25 mM	0.1502 mL	0.7511 mL	1.5022 mL	3.7554 mL
	30 mM	0.1252 mL	0.6259 mL	1.2518 mL	3.1295 mL
	40 mM	0.0939 mL	0.4694 mL	0.9389 mL	2.3472 mL
	50 mM	0.0751 mL	0.3755 mL	0.7511 mL	1.8777 mL
	60 mM	0.0626 mL	0.3130 mL	0.6259 mL	1.5648 mL
	80 mM	0.0469 mL	0.2347 mL	0.4694 mL	1.1736 mL
	100 mM	0.0376 mL	0.1878 mL	0.3755 mL	0.9389 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

sn-Glycero-3-phosphocholine-d₉ Related Classifications

Neurological Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

sn-Glycero-3-phosphocholine-d₉2260669-07-4Choline Alfoscerate-d₉Alpha-GPC-d₉L-α-GPC-d₉Isotope-Labeled CompoundsCholinesterase (ChE)Endogenous MetaboliteInhibitorinhibitorinhibit

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sn-Glycero-3-phosphocholine-d9 (Synonyms: Choline Alfoscerate-d9; Alpha-GPC-d9; L-α-GPC-d9)

Other Forms of sn-Glycero-3-phosphocholine-d9:

sn-Glycero-3-phosphocholine-d9 Related Antibodies

Recomendaciones destacadas

•Related Small Molecules:

•Related Proteins:

Ver todos los productos específicos de isoformas Cholinesterase (ChE):

Ver todos los productos específicos de isoformas Endogenous Metabolite:

Actividad biológica

Pureza y Documentación

Referencias

Revisión del cliente

sn-Glycero-3-phosphocholine-d9 Related Antibodies

Calculadora de molaridad

Calculadora de dilución

Complete Stock Solution Preparation Table

sn-Glycero-3-phosphocholine-d9 Related Classifications