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  4. NPPM 6748-481

NPPM 6748-481 is a selective inhibitor of the yeast phosphatidylinositol transfer protein (PITP) Sec14.

For research use only. We do not sell to patients.

NPPM 6748-481 Chemical Structure

NPPM 6748-481 Chemical Structure

CAS No. : 432020-20-7

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Description

NPPM 6748-481 is a selective inhibitor of the yeast phosphatidylinositol transfer protein (PITP) Sec14[1].

Molecular Weight

363.77

Formula

C17H15ClFN3O3
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(C1=CC=C(Cl)C([N+]([O-])=O)=C1)N2CCN(C3=CC=CC=C3F)CC2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (274.90 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7490 mL 13.7449 mL 27.4899 mL
5 mM 0.5498 mL 2.7490 mL 5.4980 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.60%

COA (248 KB) HNMR (267 KB) LCMS (98 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7490 mL 13.7449 mL 27.4899 mL 68.7247 mL
5 mM 0.5498 mL 2.7490 mL 5.4980 mL 13.7449 mL
10 mM 0.2749 mL 1.3745 mL 2.7490 mL 6.8725 mL
15 mM 0.1833 mL 0.9163 mL 1.8327 mL 4.5816 mL
20 mM 0.1374 mL 0.6872 mL 1.3745 mL 3.4362 mL
25 mM 0.1100 mL 0.5498 mL 1.0996 mL 2.7490 mL
30 mM 0.0916 mL 0.4582 mL 0.9163 mL 2.2908 mL
40 mM 0.0687 mL 0.3436 mL 0.6872 mL 1.7181 mL
50 mM 0.0550 mL 0.2749 mL 0.5498 mL 1.3745 mL
60 mM 0.0458 mL 0.2291 mL 0.4582 mL 1.1454 mL
80 mM 0.0344 mL 0.1718 mL 0.3436 mL 0.8591 mL
100 mM 0.0275 mL 0.1374 mL 0.2749 mL 0.6872 mL
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NPPM 6748-481 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NPPM 6748-481432020-20-7OthersInhibitorinhibitorinhibit

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