1. Stem Cell/Wnt
  2. Smo
  3. Saridegib

Saridegib (Synonyms: IPI-926; Patidegib)

Cat. No.: HY-16587 Purity: >99.0%
Handling Instructions

Saridegib is a potent and specific inhibitor of Smoothened (Smo), a key signaling transmembrane protein in the Hedgehog (Hh) pathway.

For research use only. We do not sell to patients.

Saridegib Chemical Structure

Saridegib Chemical Structure

CAS No. : 1037210-93-7

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Description

Saridegib is a potent and specific inhibitor of Smoothened (Smo), a key signaling transmembrane protein in the Hedgehog (Hh) pathway.

IC50 & Target

Smo[1].

In Vivo

Evidence from a genetically engineered mouse model of pancreatic cancer demonstrates that Saridegib (IPI-926) can deplete tumor-associated stromal tissue and increase intratumoral mean vessel density. These changes result in enhanced delivery of concurrently administered systemic agents, leading to a decreased tumor burden and prolonged survival in this mouse model[1].

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
References
Molecular Weight

504.77

Formula

C₂₉H₄₈N₂O₃S

CAS No.

1037210-93-7

SMILES
Shipping

Room temperature in continental US; may vary elsewhere

Purity: >99.0%

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Product Name:
Saridegib
Cat. No.:
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Saridegib

Cat. No.: HY-16587