2. Stem Cell/Wnt
  3. Hedgehog Smo
  4. Hedgehog IN-6

Hedgehog IN-6 (Compound Q29) is a Hedgehog (Hh) inhibitor that can be used in cancer research. Hedgehog IN-6 inhibits the hedgehog (Hh) pathway by binding to the cysteine-rich domain (CRD) of Smoothened (Smo) and blocking its cholesterization.

For research use only. We do not sell to patients.

Hedgehog IN-6 Chemical Structure

Hedgehog IN-6 Chemical Structure

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  
Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Hedgehog IN-6 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Hedgehog IN-6 (Compound Q29) is a Hedgehog (Hh) inhibitor that can be used in cancer research. Hedgehog IN-6 inhibits the hedgehog (Hh) pathway by binding to the cysteine-rich domain (CRD) of Smoothened (Smo) and blocking its cholesterization[1].

In Vitro

Q29 (1-10 μM; 24 h) dose-dependently inhibits GLI1 protein expression activated by Shh-N[1].
Q29 (1-10 μM; 24 h + 12 h) inhibits Hh signaling-dependent cell proliferation in a dose-dependent manner[1].
Q29 inhibits Gli-luciferase activity with an IC50 of 1.33 μM in the presence of different concentrations of Shh-N[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Hedgehog IN-6 Related Antibodies

Western Blot Analysis[1]

Cell Line: NIH 3T3 cells
Concentration: 1, 3, 10 μM
Incubation Time: 24 h
Result: Dose dependently decreased the protein and mRNA levels of endogenous Gli1.

Cell Proliferation Assay[1]

Cell Line: cGNP cells; medulloblastoma cells
Concentration: 1, 3, 10 μM
Incubation Time: 24 h+12h
Result: Dose dependently inhibited the growth of Shh-N-stimulated cGNP cells and medulloblastoma cells isolated from Ptch1+/P53/ mice.
In Vivo

Q29 (90 mg/kg; oral gavage; twice daily; 13 days) effectively inhibits tumor growth in Ptch1+/P53/ mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Ptch1+/P53/ mice[1]
Dosage: 90 mg/kg
Administration: p.o.; twice daily; 13 days
Result: Effectively inhibited tumor growth and exhibited synergistic inhibition with vismodegib (15 mg/kg; HY-10440)
Molecular Weight

389.61

Formula

C25H43NO2
SMILES

CC1=C(CCC(NCCCC)=O)[C@]2([H])CC[C@@]3([H])C(C)(C)[C@@H](O)CC[C@]3(C)[C@@]2([H])CC1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Hedgehog IN-6 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Hedgehog IN-6Hedgehog IN6Hedgehog IN 6HedgehogSmoSmoothenedsmoothenedcysteine-rich domainbasal cell carcinomasvismodegibmedulloblastomacholesterylationPtch1+/P53/ micecGNP cellsmedulloblastoma cellsNIH 3T3 cellsInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Hedgehog IN-6
Cat. No.:
HY-162372
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

Request for HNMR Report

We have received your request and will respond to you as soon as possible.