Hedgehog IN-6
Hedgehog IN-6 (Compound Q29) is a Hedgehog (Hh) inhibitor that can be used in cancer research. Hedgehog IN-6 inhibits the hedgehog (Hh) pathway by binding to the cysteine-rich domain (CRD) of Smoothened (Smo) and blocking its cholesterization.
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- No. CAS: 2916444-33-0
- Fòrmula: C25H43NO2
- Peso molecular:389.61
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
Descripciòn
In Vitro
Q29 (1-10 μM; 24 h) dose-dependently inhibits GLI1 protein expression activated by Shh-N[1].
Q29 (1-10 μM; 24 h + 12 h) inhibits Hh signaling-dependent cell proliferation in a dose-dependent manner[1].
Q29 inhibits Gli-luciferase activity with an IC50 of 1.33 μM in the presence of different concentrations of Shh-N[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:NIH 3T3 cells
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Concentration:1, 3, 10 μM
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Incubation Time:24 h
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Result:Dose dependently decreased the protein and mRNA levels of endogenous Gli1.
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Cell Line:cGNP cells; medulloblastoma cells
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Concentration:1, 3, 10 μM
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Incubation Time:24 h+12h
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Result:Dose dependently inhibited the growth of Shh-N-stimulated cGNP cells and medulloblastoma cells isolated from Ptch1+/P53/ mice.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Ptch1+/P53/ mice[1]
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Dosage:90 mg/kg
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Administration:p.o.; twice daily; 13 days
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Result:Effectively inhibited tumor growth and exhibited synergistic inhibition with vismodegib (15 mg/kg; HY-10440)
Chemical Information
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No. CAS 2916444-33-0
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Peso molecular 389.61
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Fòrmula C25H43NO2
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SMILES
CC1=C(CCC(NCCCC)=O)[C@]2([H])CC[C@@]3([H])C(C)(C)[C@@H](O)CC[C@]3(C)[C@@]2([H])CC1
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Hedgehog IN-6 Related Classifications
HY-162372 Related Classifications
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