2. Signaling Pathways
  3. Stem Cell/Wnt
  4. Smo
  5. Smo Agonist

Smo Agonist

Smo Agonists (8):

Cat. No. Product Name Effect Purity
  • HY-12848
    SAG
    		Agonist 99.79%
    SAG is a potent Smoothened (Smo) receptor agonist (EC50=3 nM; Kd=59 nM). SAG activates the Hedgehog signaling pathway and counteracts Cyclopamine (HY-17024) inhibition of Smo.
  • HY-12848B
    SAG hydrochloride
    		Agonist 99.63%
    SAG hydrochloride is a potent Smoothened (Smo) receptor agonist (EC50=3 nM; Kd=59 nM). SAG hydrochloride activates the Hedgehog signaling pathway and counteracts Cyclopamine (HY-17024) inhibition of Smo.
  • HY-12848C
    SAG dihydrochloride
    		Agonist
    SAG dihydrochloride is a potent Smoothened (Smo) receptor agonist (EC50=3 nM; Kd=59 nM). SAG dihydrochloride activates the Hedgehog signaling pathway and counteracts Cyclopamine (HY-17024) inhibition of Smo.
  • HY-12317
    GSA-10
    		Agonist 98.01%
    GSA-10 is a potent smooth (Smo) receptor agonist. GSA-10 is a potent osteogenic molecule. GSA-10 can mediate Hedgehog (Hh) signaling. GSA-10 can be used in regenerative medicine for cancer disease and in the study of fat development.
  • HY-B0877
    Halcinonide
    		Agonist 99.56%
    Halcinonide (SQ-18566) is a high potency corticosteroid used topically in the treatment of certain skin conditions.
  • HY-B0603
    Fluticasone
    		Agonist
    Fluticasone is an inhaled corticosteroid used for respiratory research. Fluticasone is a Smo agonist with an IC50 value of 99 nM. Fluticasone activates Hedgehog signaling and promotes the proliferation of primary neuronal stem or precursor cells.
  • HY-15108G
    Purmorphamine (GMP)
    		Agonist
    Purmorphamine (GMP) is Purmorphamine (HY-15108) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Purmorphamine is a smoothened/Smo receptor agonist with an EC50 of 1 μM.
  • HY-12848A
    (Rac)-SAG
    		Agonist
    (Rac)-SAG is an isoform of SAG (HY-12848). SAG is a potent Smoothened (Smo) receptor agonist (EC50=3 nM; Kd=59 nM). SAG activates the Hedgehog signaling pathway and counteracts Cyclopamine (HY-17024) inhibition of Smo.