3093-35-4
Chemical Structure
Halcinonide
Synonym(s): SQ-18566
- CAS No.: 3093-35-4
- Formula:C24H32ClFO5
- Molecular Weight:454.96
IUPAC Name: (6aS,6bR,7S,8aS,8bS,11aR,12aS,12bS)-8b-(2-chloroacetyl)-6b-fluoro-7-hydroxy-6a,8a,10,10-tetramethyl-1,2,5,6,6a,6b,7,8,8a,8b,11a,12,12a,12b-tetradecahydro-4H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-4-one
InChIKey: MUQNGPZZQDCDFT-JNQJZLCISA-N
SMILES: C[C@@]12[C@@]3(C(CCl)=O)[C@@](OC(C)(O3)C)([H])C[C@@]1([H])[C@]4([H])CCC5=CC(CC[C@]5(C)[C@@]4(F)[C@@H](O)C2)=O
Biological Activity: Halcinonide (SQ-18566) is an orally active Smoothened (Smo) agonist. Halcinonide activates the Hedgehog signaling pathway by binding to Smo and promoting its internalization and expression, thereby activating Gli transcription factors. Halcinonide not only stimulates cell proliferation, increases the expression of cyclin D2/CDK6 and inhibits the degradation of caspase-3, but also suppresses Bcl-2/Bax-mediated apoptosis, oxidative stress and inflammatory responses. Halcinonide activates RxRγ to upregulate the expression of myelin genes, thereby reducing cerebral infarction and improving behavioral deficits. Halcinonide has been used in studies related to multiple sclerosis and ischemic stroke[1][2][3].
| Cat. No. | 상품명 | Purity | 제품 설명 | Pricing | |||||||||||||||||||
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Halcinonide | 98.29% | Halcinonide (SQ-18566) is an orally active Smoothened (Smo) agonist. Halcinonide activates the Hedgehog signaling pathway by binding to Smo and promoting its internalization and expression, thereby activating Gli transcription factors. Halcinonide not only stimulates cell proliferation, increases the expression of cyclin D2/CDK6 and inhibits the degradation of caspase-3, but also suppresses Bcl-2/Bax-mediated apoptosis, oxidative stress and inflammatory responses. Halcinonide activates RxRγ to upregulate the expression of myelin genes, thereby reducing cerebral infarction and improving behavioral deficits. Halcinonide has been used in studies related to multiple sclerosis and ischemic stroke. | ||||||||||||||||||||
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Halcinonide (Standard) | ≥98% | Halcinonide (Standard) is the analytical standard of Halcinonide. This product is intended for research and analytical applications. Halcinonide (SQ-18566) is a high potency corticosteroid used topically in the treatment of certain skin conditions. | ||||||||||||||||||||
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Similarity Score 0.75
HY-B0636RTriamcinolone acetonide (Standard) -
Similarity Score 0.75
HY-B0636S1Triamcinolone acetonide-13C3 -
Similarity Score 0.71
HY-Z7974Clobetasol propionate impurity 4 -
Similarity Score 0.71
HY-W340872Triamcinolone acetonide acetate -
Similarity Score 0.70
HY-W74038021-Carboxylic acid triamcinolone acetonide -
Similarity Score 0.69
HY-Z34871,2-Dihydro dexamethasone -
Similarity Score 0.68
HY-U00103RTriamcinolone hexacetonide (Standard) -
Similarity Score 0.68
HY-B0415Fluocinolone (Acetonide) -
Similarity Score 0.68
HY-W777281Fluocinolone acetonide-13C3 -
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References
- [1]. Porcu G, et al. Clobetasol and Halcinonide Act as Smoothened Agonists to Promote Myelin Gene Expression and RxRγ Receptor Activation. PLoS One. 2015;10(12):e0144550. Published 2015 Dec 10. [Content Brief]
- [2]. Wang J, et al. Identification of select glucocorticoids as Smoothened agonists: potential utility for regenerative medicine. Proc Natl Acad Sci U S A. 2010;107(20):9323-9328. [Content Brief]
- [3]. Liu J, et al. Halcinonide activates smoothened to ameliorate ischemic stroke injury. Life Sci. 2025;361:123324. [Content Brief]
