1. Protein Tyrosine Kinase/RTK
    Autophagy
  2. c-Met/HGFR
    Autophagy
  3. Tepotinib

Tepotinib (Synonyms: EMD-1214063)

Cat. No.: HY-14721 Purity: 99.87%
Handling Instructions

Tepotinib (EMD-1214063) is a potent and selective c-Met inhibitor with IC50 of 4 nM, >200-fold selective for c-Met than IRAK4, TrkA, Axl, IRAK1, and Mer.

For research use only. We do not sell to patients.

Tepotinib Chemical Structure

Tepotinib Chemical Structure

CAS No. : 1100598-32-0

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in DMSO USD 165 In-stock
Estimated Time of Arrival: December 31
5 mg USD 150 In-stock
Estimated Time of Arrival: December 31
10 mg USD 240 In-stock
Estimated Time of Arrival: December 31
50 mg USD 480 In-stock
Estimated Time of Arrival: December 31
100 mg USD 840 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 4 publication(s) in Google Scholar

Top Publications Citing Use of Products

    Tepotinib purchased from MCE. Usage Cited in: Gene Expr. 2018 May 18;18(2):135-147.

    Western blot for Myc-tag shows decrease in Myc-tag levels at 8 weeks of EMD1214063 treatment only. GAPDH shows comparable loading in all lanes.
    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Tepotinib (EMD-1214063) is a potent and selective c-Met inhibitor with IC50 of 4 nM, >200-fold selective for c-Met than IRAK4, TrkA, Axl, IRAK1, and Mer.

    Clinical Trial
    Molecular Weight

    492.57

    Formula

    C₂₉H₂₈N₆O₂

    CAS No.

    1100598-32-0

    SMILES

    N#CC1=CC=CC(C(C=CC2=O)=NN2CC3=CC=CC(C4=NC=C(C=N4)OCC5CCN(CC5)C)=C3)=C1

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : 28.57 mg/mL (58.00 mM; ultrasonic and adjust pH to 5 with HCl)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.0302 mL 10.1508 mL 20.3017 mL
    5 mM 0.4060 mL 2.0302 mL 4.0603 mL
    10 mM 0.2030 mL 1.0151 mL 2.0302 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 0.62 mg/mL (1.26 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 0.62 mg/mL (1.26 mM); Clear solution

    • 3.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 0.62 mg/mL (1.26 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    References

    Purity: 99.87%

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    Keywords:

    TepotinibEMD-1214063EMD1214063EMD 1214063c-Met/HGFRAutophagyInhibitorinhibitorinhibit

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