Tasquinimod-d3
Based on 1 Customer Validation
Tasquinimod-d3 (ABR-215050-d3) is the deuterium labeled Tasquinimod (HY-10528). Tasquinimod is an oral antiangiogenic agent, which plays an important role in castration-resistant prostate cancer. Tasquinimod binds to the regulatory Zn2+ binding domain of HDAC4 with Kd of 10-30 nM. Tasquinimod also is a S100A9 inhibitor.
For research use only. We do not sell to patients.
- Purity: 99.34%
- CAS No.: 1416701-99-9
- Formula: C20H14D3F3N2O4
- Molecular Weight:409.37
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 1416701-99-9
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Unlabeled Cas 254964-60-8
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Appearance Solid
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Molecular Weight 409.37
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Formula C20H14D3F3N2O4
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Color White to off-white
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SMILES
O=C(N(C1=CC=C(C=C1)C(F)(F)F)C([2H])([2H])[2H])C2=C(C3=C(C=CC=C3OC)N(C2=O)C)O
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Synonyms
ABR-215050-d3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (244.28 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Isaacs JT, et al. Tasquinimod Is an Allosteric Modulator of HDAC4 survival signaling within the compromised cancer microenvironment. Cancer Res. 2013 Feb 15;73(4):1386-99. [Content Brief]
[2]. Isaacs JT, et al. Anti-cancer potency of tasquinimod is enhanced via albumin-binding facilitating increased uptake in the tumor microenvironment. Oncotarget. 2014 Sep 30;5(18):8093-106. [Content Brief]
[3]. Olsson A, et al. Tasquinimod (ABR-215050), a quinoline-3-carboxamide anti-angiogenic agent, modulates the expression of thrombospondin-1 in human prostate tumors. Mol Cancer. 2010 May 17;9:107. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.4428 mL | 12.2139 mL | 24.4278 mL | 61.0694 mL |
| 5 mM | 0.4886 mL | 2.4428 mL | 4.8856 mL | 12.2139 mL | |
| 10 mM | 0.2443 mL | 1.2214 mL | 2.4428 mL | 6.1069 mL | |
| 15 mM | 0.1629 mL | 0.8143 mL | 1.6285 mL | 4.0713 mL | |
| 20 mM | 0.1221 mL | 0.6107 mL | 1.2214 mL | 3.0535 mL | |
| 25 mM | 0.0977 mL | 0.4886 mL | 0.9771 mL | 2.4428 mL | |
| 30 mM | 0.0814 mL | 0.4071 mL | 0.8143 mL | 2.0356 mL | |
| 40 mM | 0.0611 mL | 0.3053 mL | 0.6107 mL | 1.5267 mL | |
| 50 mM | 0.0489 mL | 0.2443 mL | 0.4886 mL | 1.2214 mL | |
| 60 mM | 0.0407 mL | 0.2036 mL | 0.4071 mL | 1.0178 mL | |
| 80 mM | 0.0305 mL | 0.1527 mL | 0.3053 mL | 0.7634 mL | |
| 100 mM | 0.0244 mL | 0.1221 mL | 0.2443 mL | 0.6107 mL |
Tasquinimod-d3 Related Classifications
HY-10528S Related Classifications
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