1416701-99-9
1416701-99-9
Chemical Structure
Tasquinimod-d3
Synonym(s): ABR-215050-d3
- CAS No.: 1416701-99-9
- Formula:C20H14D3F3N2O4
- Molecular Weight:409.37
InChIKey: ONDYALNGTUAJDX-FIBGUPNXSA-N
SMILES: O=C(N(C1=CC=C(C=C1)C(F)(F)F)C([2H])([2H])[2H])C2=C(C3=C(C=CC=C3OC)N(C2=O)C)O
Biological Activity: Tasquinimod-d3 (ABR-215050-d3) is the deuterium labeled Tasquinimod (HY-10528). Tasquinimod is an oral antiangiogenic agent, which plays an important role in castration-resistant prostate cancer. Tasquinimod binds to the regulatory Zn2+ binding domain of HDAC4 with Kd of 10-30 nM. Tasquinimod also is a S100A9 inhibitor[1][2][3].
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Tasquinimod-d3 | 99.34% | Tasquinimod-d3 (ABR-215050-d3) is the deuterium labeled Tasquinimod (HY-10528). Tasquinimod is an oral antiangiogenic agent, which plays an important role in castration-resistant prostate cancer. Tasquinimod binds to the regulatory Zn2+ binding domain of HDAC4 with Kd of 10-30 nM. Tasquinimod also is a S100A9 inhibitor. | ||||||||||||||||||||
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Tasquinimod (Standard) | ≥98% | Tasquinimod (Standard) is the analytical standard of Tasquinimod. This product is intended for research and analytical applications. Tasquinimod is an oral antiangiogenic agent, which has the potential for castration-resistant prostate cancer treatment. Tasquinimod binds to the regulatory Zn2+ binding domain of HDAC4 with Kd of 10-30 nM. Tasquinimod also is a S100A9 inhibitor. | ||||||||||||||||||||
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Tasquinimod | 99.70% | Tasquinimod is an oral antiangiogenic agent, which has the potential for castration-resistant prostate cancer treatment. Tasquinimod binds to the regulatory Zn2+ binding domain of HDAC4 with Kd of 10-30 nM. Tasquinimod also is a S100A9 inhibitor. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.65
HY-13743Roquinimex -
Similarity Score 0.62
HY-W062904Laquinimod sodium -
Similarity Score 0.62
HY-13010Laquinimod -
Similarity Score 0.60
HY-100442Paquinimod -
Similarity Score 0.54
HY-13010SLaquinimod-d5 -
Similarity Score 0.51
HY-12317GSA-10 -
Similarity Score 0.51
HY-175340Kv7.2/Kv7.3 activator-3 -
Similarity Score 0.49
HY-15468AIOX2 sodium -
Similarity Score 0.49
HY-15468IOX2 -
Explore the MedChemAI to find more analogs
References
- [1]. Isaacs JT, et al. Tasquinimod Is an Allosteric Modulator of HDAC4 survival signaling within the compromised cancer microenvironment. Cancer Res. 2013 Feb 15;73(4):1386-99. [Content Brief]
- [2]. Isaacs JT, et al. Anti-cancer potency of tasquinimod is enhanced via albumin-binding facilitating increased uptake in the tumor microenvironment. Oncotarget. 2014 Sep 30;5(18):8093-106. [Content Brief]
- [3]. Olsson A, et al. Tasquinimod (ABR-215050), a quinoline-3-carboxamide anti-angiogenic agent, modulates the expression of thrombospondin-1 in human prostate tumors. Mol Cancer. 2010 May 17;9:107. [Content Brief]
