IOX2 sodium
Based on 21 publication(s) in Google Scholar
IOX2 sodium is a specific prolyl hydroxylase-2 (PHD2) inhibitor with IC50 of 22 nM. IOX2 sodium regulates platelet function and arterial thrombosis by upregulating HIF-1α expression and inhibiting ROS production. IOX2 sodium can be used in the study of thrombotic diseases.
For research use only. We do not sell to patients.
- CAS No.: 2377239-85-3
- Formula: C19H15N2NaO5
- Molecular Weight:374.32
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Publications Citing Use of MedChemExpress (MCE) IOX2 sodium
More- Nat Commun. 2026 Feb 12;17(1):1214. [Abstract]
- Nat Commun. 2022 May 4;13(1):2447. [Abstract]
- Acta Pharm Sin B. 2025 Mar;15(3):1497-1513. [Abstract]
- EMBO J. 2025 May;44(9):2514-2540. [Abstract]
- Cell Rep. 2024 Nov 10;43(11):114915. [Abstract]
- Thromb Haemost. 2022 Oct;122(10):1693-1705. [Abstract]
- Sci Rep. 2026 Jun 20. [Abstract]
- Sci Rep. 2025 Oct 14;15(1):35804. [Abstract]
- Sci Rep. 2022 Jan 27;12(1):1443. [Abstract]
- Mediators Inflamm. 2021 Aug 5:2021:9958281. [Abstract]
- Eur J Med Res. 2026 Mar 31;31(1):693.
- J Virol. 2026 Apr 27:e0149525. [Abstract]
- ChemistrySelect. 2025 Mar 31.
- Mol Biol. 2026 Mar 10.
- Patent. US20250262229A1.
- Ghent University. 2024.
- bioRxiv. 2024 November 19.
- Aging (Albany NY). 2021 May 20;13(10):14355-14371. [Abstract]
- Oxid Med Cell Longev. 2020 Jan 4:2020:4909103. [Abstract]
- Patent. US20180263995A1.
- Hypoxia. 2016 Nov 8:4:147-159. [Abstract]
Customer Validation & Images
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Cell Migration/Invasion Assay
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WB
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RT-PCR
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Cell Proliferation/Viability Assay
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Flow Cytometry
Biological Activity
IC50: 22 nM (PHD2)[2]
IOX2 sodium (0, 10, 25, and 50 μM) dose-dependently inhibits collagen-related peptide (CRP; 0.25 μg/mL) or thrombin (0.03 U/mL)-induced platelet aggregation and ATP release. But IOX2 doesn’t affect P-selectin expression and the surface levels of glycoprotein (GP)Ibα, GPVI, or αIIbβ3[1].
IOX2 sodium also inhibits the spreading of platelets on fibrinogen or collagen and clot retraction[1].
IOX2 sodium (50 μM; 24 h) increases the transcription level of VEGF-A and BNIP3 in Normal human epidermal keratinocytes (NHEK) and Normal human dermal fibroblasts (NHDF), when grown under normoxia and hypoxia condition[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Mouse[1]
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Dosage:10 mg/kg
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Administration:Intraperitoneal injection
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Result:Upregulated HIF-1α in platelets, decreased ROS generation, and downregulated NOX1 expression.
Increased the phosphorylation level of VASP (Ser157/239), and inhibited the phosphorylation of p38 (Thr180/Tyr182), ERK1/2 (Thr202/Tyr204), AKT (Thr308/Ser473), and PKCδ (Thr505) in CRP- or thrombin-stimulated platelets.
Chemical Information
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CAS No. 2377239-85-3
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Molecular Weight 374.32
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Formula C19H15N2NaO5
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SMILES
O=C(O[Na])CNC(C1=C(O)C2=C(N(CC3=CC=CC=C3)C1=O)C=CC=C2)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (21)
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Journal Impact Factor
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Most Recent
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Nat Commun
Human iPSC-based Modeling of Pulmonary Fibrosis Reveals p300/CBP Inhibition Suppresses Alveolar Transitional Cell State. [Abstract]2026 Feb 12;17(1):1214. PMID: 41680175 -
Nat Commun
Dual functions of microRNA-17 in maintaining cartilage homeostasis and protection against osteoarthritis. [Abstract]2022 May 4;13(1):2447. PMID: 35508470
IOX2 sodium purchased from MedChemExpress. Usage Cited in: Nat Commun. 2022 May 4;13(1):2447. [Abstract]
Mouse articular chondrocytes were transfected with miR-17 inhibitor (100 nM) or inhibitor NC or miR-17 mimic (50 nM) or mimic NC and treated with or without IOX2 (20 μM) for 72 h. The protein levels of HIF-1α, SOX9, COL2A1 and MMP2 were determined by western blot.
IOX2 sodium purchased from MedChemExpress. Usage Cited in: Nat Commun. 2022 May 4;13(1):2447. [Abstract]
Mouse articular chondrocytes were transfected with miR-17 inhibitor (100 nM) or inhibitor NC or miR-17 mimic (50 nM) or mimic NC and treated with or without IOX2 (20 μM) for 72 h. The gene expression of P3h3, Plod2, and Lox were determined by qRT-PCR.
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Acta Pharm Sin B
Ginsenoside CK targets PHD2 to prevent platelet adhesion and enhance blood circulation by modifying the three-dimensional arrangement of collagen. [Abstract]2025 Mar;15(3):1497-1513. PMID: 40370536 -
EMBO J
SIRT5-mediated desuccinylation of PPA2 enhances HIF-1alpha-dependent adaptation to hypoxic stress and colorectal cancer metastasis. [Abstract]2025 May;44(9):2514-2540. PMID: 40164945 -
Cell Rep
Metabolic disruption exacerbates intestinal damage during sleep deprivation by abolishing HIF1α-mediated repair. [Abstract]2024 Nov 10;43(11):114915. PMID: 39527478 -
Thromb Haemost
2022 Oct;122(10):1693-1705. PMID: 35477177 -
Sci Rep
Deciphering glutamine metabolic reprogramming: a novel therapeutic target ALDH18A1 in triple-negative breast cancer. [Abstract]2026 Jun 20. PMID: 42323345 -
Sci Rep
EGLN1 inhibition reverses angiogenesis impairment in hyperglycemia by activating autophagy. [Abstract]2025 Oct 14;15(1):35804. PMID: 41087486
IOX2 sodium purchased from MedChemExpress. Usage Cited in: Sci Rep. 2025 Oct 14;15(1):35804. [Abstract]
Representative images and quantification of wound healing assay in HUVECs stimulated by high glucose combined with DMSO or IOX2 (50 μM) at 12 and 24 h.
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Sci Rep
Hypoxia-induced HIF1α activation regulates small extracellular vesicle release in human embryonic kidney cells. [Abstract]2022 Jan 27;12(1):1443. PMID: 35087095 -
Mediators Inflamm
Hypoxia-Inducible Factor-1 α in Macrophages, but Not in Neutrophils, Is Important for Host Defense during Klebsiella pneumoniae-Induced Pneumosepsis. [Abstract]2021 Aug 5:2021:9958281. PMID: 34393650 -
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J Virol
PTBP1 is upregulated in response to Zika virus infection and restrains viral replication by hijacking viral NS1 protein to induce NS1 degradation. [Abstract]2026 Apr 27:e0149525. PMID: 42037413 -
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Aging (Albany NY)
κ-opioid receptor stimulation alleviates rat vascular smooth muscle cell calcification via PFKFB3-lactate signaling. [Abstract]2021 May 20;13(10):14355-14371. PMID: 34016793 -
Oxid Med Cell Longev
Direct Peritoneal Resuscitation with Pyruvate Protects the Spinal Cord and Induces Autophagy via Regulating PHD2 in a Rat Model of Spinal Cord Ischemia-Reperfusion Injury. [Abstract]2020 Jan 4:2020:4909103. PMID: 31998438
IOX2 sodium purchased from MedChemExpress. Usage Cited in: Oxid Med Cell Longev. 2020 Jan 4:2020:4909103. [Abstract]
The result of CCK-8 showed 500 μM of IOX2 was cytotoxic in comparison to others.
IOX2 sodium purchased from MedChemExpress. Usage Cited in: Oxid Med Cell Longev. 2020 Jan 4:2020:4909103. [Abstract]
Flow cytometry displays the apoptosis rate is increased in the OGD/R group, while downregulated by pyruvate/IOX2.
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Hypoxia
2016 Nov 8:4:147-159. PMID: 27878135
Purity & Documentation
References
[1]. Gu W, et al. Inhibition of Hypoxia-Inducible Factor Prolyl-Hydroxylase Modulates Platelet Function. Thromb Haemost. 2022 Oct;122(10):1693-1705. [Content Brief]
[2]. Deppe J, et al. Impairment of hypoxia-induced HIF-1α signaling in keratinocytes and fibroblasts by sulfur mustard is counteracted by a selective PHD-2 inhibitor. Arch Toxicol. 2016 May;90(5):1141-50. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
IOX2 sodium Related Classifications
HY-15468A Related Classifications
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