2. Metabolic Enzyme/Protease
  3. HIF/HIF Prolyl-Hydroxylase
  4. IOX2 sodium

IOX2 sodium is a specific prolyl hydroxylase-2 (PHD2) inhibitor with IC50 of 22 nM. IOX2 sodium regulates platelet function and arterial thrombosis by upregulating HIF-1α expression and inhibiting ROS production. IOX2 sodium can be used in the study of thrombotic diseases.

For research use only. We do not sell to patients.

CAS No. : 2377239-85-3

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IOX2 sodium Related Antibodies

Top Publications Citing Use of Products

    IOX2 sodium purchased from MedChemExpress. Usage Cited in: Sci Rep. 2025 Oct 14;15(1):35804.  [Abstract]

    Representative images and quantification of wound healing assay in HUVECs stimulated by high glucose combined with DMSO or IOX2 (50 μM) at 12 and 24 h.

    IOX2 sodium purchased from MedChemExpress. Usage Cited in: Nat Commun. 2022 May 4;13(1):2447.  [Abstract]

    Mouse articular chondrocytes were transfected with miR-17 inhibitor (100 nM) or inhibitor NC or miR-17 mimic (50 nM) or mimic NC and treated with or without IOX2 (20 μM) for 72 h. The protein levels of HIF-1α, SOX9, COL2A1 and MMP2 were determined by western blot.

    IOX2 sodium purchased from MedChemExpress. Usage Cited in: Nat Commun. 2022 May 4;13(1):2447.  [Abstract]

    Mouse articular chondrocytes were transfected with miR-17 inhibitor (100 nM) or inhibitor NC or miR-17 mimic (50 nM) or mimic NC and treated with or without IOX2 (20 μM) for 72 h. The gene expression of P3h3, Plod2, and Lox were determined by qRT-PCR.

    IOX2 sodium purchased from MedChemExpress. Usage Cited in: Oxid Med Cell Longev. 2020 Jan 4;2020:4909103.  [Abstract]

    The result of CCK-8 showed 500 μM of IOX2 was cytotoxic in comparison to others.

    IOX2 sodium purchased from MedChemExpress. Usage Cited in: Oxid Med Cell Longev. 2020 Jan 4;2020:4909103.  [Abstract]

    Flow cytometry displays the apoptosis rate is increased in the OGD/R group, while downregulated by pyruvate/IOX2.

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    HIF-1α HIF

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    Description

    IOX2 sodium is a specific prolyl hydroxylase-2 (PHD2) inhibitor with IC50 of 22 nM. IOX2 sodium regulates platelet function and arterial thrombosis by upregulating HIF-1α expression and inhibiting ROS production. IOX2 sodium can be used in the study of thrombotic diseases[1][2].

    IC50 & Target

    IC50: 22 nM (PHD2)[2]
    In Vitro

    IOX2 sodium (0, 10, 25, and 50 μM) dose-dependently inhibits collagen-related peptide (CRP; 0.25 μg/mL) or thrombin (0.03 U/mL)-induced platelet aggregation and ATP release. But IOX2 doesn’t affect P-selectin expression and the surface levels of glycoprotein (GP)Ibα, GPVI, or αIIbβ3[1].
    IOX2 sodium also inhibits the spreading of platelets on fibrinogen or collagen and clot retraction[1].
    IOX2 sodium (50 μM; 24 h) increases the transcription level of VEGF-A and BNIP3 in Normal human epidermal keratinocytes (NHEK) and Normal human dermal fibroblasts (NHDF), when grown under normoxia and hypoxia condition[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    IOX2 sodium Related Antibodies
    In Vivo

    IOX2 sodium (10 mg/kg; i.p.; single dose) impaired the in vivo hemostatic function of platelets and arterial thrombus formation in mice[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Mouse[1]
    Dosage: 10 mg/kg
    Administration: Intraperitoneal injection
    Result: Upregulated HIF-1α in platelets, decreased ROS generation, and downregulated NOX1 expression.
    Increased the phosphorylation level of VASP (Ser157/239), and inhibited the phosphorylation of p38 (Thr180/Tyr182), ERK1/2 (Thr202/Tyr204), AKT (Thr308/Ser473), and PKCδ (Thr505) in CRP- or thrombin-stimulated platelets.
    Molecular Weight

    374.32

    Formula

    C19H15N2NaO5
    CAS No.
    SMILES

    O=C(O[Na])CNC(C1=C(O)C2=C(N(CC3=CC=CC=C3)C1=O)C=CC=C2)=O
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Purity & Documentation
    References
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    IOX2 sodium Related Classifications

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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    IOX22377239-85-3IOX 2IOX-2HIF/HIF Prolyl-HydroxylaseHypoxia-inducible factorsHIFsHIF-PHInhibitorinhibitorinhibit

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