1. Apoptosis
  2. TNF Receptor
  3. Roquinimex

Roquinimex (Synonyms: Linomide; FCF89; ABR212616)

Cat. No.: HY-13743 Purity: 98.93%
Handling Instructions

Roquinimex (Linomide; PNU212616; ABR212616) is a quinoline derivative immunostimulant which increases NK cell activity and macrophage cytotoxicity; inhibits angiogenesis and reduces the secretion of TNF alpha.

For research use only. We do not sell to patients.

Roquinimex Chemical Structure

Roquinimex Chemical Structure

CAS No. : 84088-42-6

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Solution
10 mM * 1 mL in DMSO USD 83 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 83 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 75 In-stock
Estimated Time of Arrival: December 31
10 mg USD 120 In-stock
Estimated Time of Arrival: December 31
50 mg USD 470 In-stock
Estimated Time of Arrival: December 31
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Description

Roquinimex (Linomide; PNU212616; ABR212616) is a quinoline derivative immunostimulant which increases NK cell activity and macrophage cytotoxicity; inhibits angiogenesis and reduces the secretion of TNF alpha. IC50 value: Target: TNF alpha Prophylactic administration of DSS-treated mice with roquinimex significantly reduced clinical signs of colitis, MDS and the CH-reduction. Moreover, in roquinimex treated animals, the MPO activity was significantly reduced by more than 50% compared to DSS control mice. Notably, therapeutic administration of roquinimex in DSS-treated mice also significantly inhibited the MDS, CH-reduction and MPO activity [2]. Linomide, a synthetic immunomodulator, at concentrations effective in vivo reduces the number of MBP-reactive TNF-alpha and increases MBP-reactive IL-10 and TGF-beta mRNA expressing MNC from MS patients' blood when analysed in vitro. Compared to dexamethasone, Linomide up-regulated levels of blood MNC expressing mRNA of TGF-beta after culture in presence of MBP [3].

Molecular Weight

308.33

Formula

C18H16N2O3

CAS No.
SMILES

O=C(C1=C(O)C2=C(N(C)C1=O)C=CC=C2)N(C)C3=CC=CC=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 83.3 mg/mL (270.17 mM)

*"≥" means soluble, but saturation unknown.

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Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2433 mL 16.2164 mL 32.4328 mL
5 mM 0.6487 mL 3.2433 mL 6.4866 mL
10 mM 0.3243 mL 1.6216 mL 3.2433 mL
*Please refer to the solubility information to select the appropriate solvent.
References

Purity: 98.93%

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