Structure-activity relationships studies of the anti-angiogenic activities of linomide

  • Bioorg Med Chem Lett. 2003 Mar 24;13(6):1187-9. doi: 10.1016/s0960-894x(03)00047-7.
Jiandong Shi  1 ,  Zili Xiao ,  Michael A Ihnat ,  Chandrashekhar Kamat ,  Bulbul Pandit ,  Zhigen Hu ,  Pui-Kai Li
Affiliations
  • 1. Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA.
PMID: 12643940 DOI: 10.1016/s0960-894x(03)00047-7
Abstract

The synthesis and anti-angiogenic activities of linomide and its analogues are reported. Three of the analogues are 3.3-69 times more potent than linomide at inhibiting blood vessel formation in the CAM angiogenesis assay. These compounds possessed considerable anti-proliferative activity against isolated HUVEC cells with no activity against epithelial-derived prostate tumor cells.