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  3. Cetrimonium bromide

Cetrimonium bromide  (Synonyms: CTAB; Cetyltrimethylammonium bromide; Hexadecyltrimethylammonium bromide)

Cat. No.: HY-B1260 Purity: ≥98.0%
COA Handling Instructions

Cetrimonium bromide (CTAB), a quaternary ammonium, is an orally active cationic surfaetant. Cetrimonium bromide has toxicity and anticancer effect. Cetrimonium bromide inhibits cell migration and invasion through modulating the canonical and non-canonical TGF-β signaling pathways. Cetrimonium bromide can be used for DNA extraction.

For research use only. We do not sell to patients.

Cetrimonium bromide Chemical Structure

Cetrimonium bromide Chemical Structure

CAS No. : 57-09-0

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Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
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Solid
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Based on 1 publication(s) in Google Scholar

Other Forms of Cetrimonium bromide:

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1 Publications Citing Use of MCE Cetrimonium bromide

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Cetrimonium bromide (CTAB), a quaternary ammonium, is an orally active cationic surfaetant. Cetrimonium bromide has toxicity and anticancer effect. Cetrimonium bromide inhibits cell migration and invasion through modulating the canonical and non-canonical TGF-β signaling pathways. Cetrimonium bromide can be used for DNA extraction[1][2][3][4].

IC50 & Target

MMP-9

 

MMP-2

 

In Vitro

Cetrimonium bromide (1-5 μM, 24 h) cannot affect growth of SK-HEP-1 cells[1].
Cetrimonium bromide (5 μM, 16-24 h) attenuates cellular migration and invasion of SK-HEP-1cells[1].
Cetrimonium bromide (5 μM, 24 h) inhibits the protein expression of MMP-2 and MMP-9, increases the protein expression of TIMP-1 and TIMP-2 and restrain the protein expression of Rac1, cdc42 and RhoA in SK-HEP-1cells[1].
Cetrimonium bromide (5 μM, 12-72 h) induces apoptosis in human Head and neck cancer (HNC) cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: SK-HEP-1 cells
Concentration: 1 μM, 2.5 μM, 5 μM
Incubation Time: 24 h
Result: Retained more than 90% cell viability at 24 hours.

Cell Cycle Analysis[2]

Cell Line: HNC cells
Concentration: 5 μM
Incubation Time: 12 h, 24 h, 48 h, 72 h
Result: Induced caspase activation.
Observed the activation of the caspase cascade and increased in a time-dependent manner.

Western Blot Analysis[1]

Cell Line: SK-HEP-1 cells
Concentration: 1 μM, 2.5 μM, 5 μM
Incubation Time: 24 h
Result: Significantly down-regulates MMP-2 and MMP-9 expressions in SK-HEP-1 cells in a dose-dependent manner.
Significantly increased the protein expression of TIMP-1 and TIMP-2.
Negatively affects the protein levels of Rac1, cdc42 and RhoA in SK-HEP-1 cells.
In Vivo

Cetrimonium bromide (5 mg/kg, Intraperitoneal injection, once a day for five consecutive days) ablated tumor-forming capacity of FaDu cells and delayed growth of established tumors in FaDu cells tumor-bearing mice[2].
Cetrimonium bromide (10-45 mg/kg, Supplemented in drinking water, once a day for 1 year) has subacute and chronic toxicity in the rat[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: FaDu cells tumor-bearing mice[2]
Dosage: 5 mg/kg
Administration: Intraperitoneal injection (i.p.)
Result: Induced a modest reduction in tumor development.
Delayed the mean time to reach a tumor-plus-leg diameters (TLD) of 14mm by ~3.7 days.
Animal Model: Sprague-Dawley rats[3]
Dosage: 10 mg/kg, 20 mg/kg, 45 mg/kg
Administration: Supplemented in drinking water
Result: Showed lower body weight at highest concentration within 3 weeks.
Reduced the body weight throughout the experimental in males and skeletal growth at highest dose level in both males and females.
Significantly decreased efficiency of food conversion in male rats receiving the highest dose.
Molecular Weight

364.45

Formula

C19H42BrN

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CCCCCCCCCCCCCCCC[N+](C)(C)C.[Br-]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 10 mg/mL (27.44 mM; Need ultrasonic)

H2O : 4.55 mg/mL (12.48 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7439 mL 13.7193 mL 27.4386 mL
5 mM 0.5488 mL 2.7439 mL 5.4877 mL
10 mM 0.2744 mL 1.3719 mL 2.7439 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  PBS

    Solubility: 50 mg/mL (137.19 mM); Clear solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 1 mg/mL (2.74 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 1 mg/mL (2.74 mM); Clear solution

  • 4.

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 1 mg/mL (2.74 mM); Clear solution

*All of the co-solvents are available by MedChemExpress (MCE).
Purity & Documentation

Purity: ≥98.0%

References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Cetrimonium bromide
Cat. No.:
HY-B1260
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