Quinolinic acid-d3
Based on 2 publication(s) in Google Scholar
Quinolinic acid-d3 is the deuterium labeled Quinolinic acid. Quinolinic acid, an endogenous metabolite of tryptophan, is a N-methyl-D-aspartate receptor (NMDA receptor) agonist. Quinolinic acid increases glutamate efflux, induces the generation of ROS, activates nitric oxide synthase, produces excessive NO, leading to calcium ion influx and neuronal apoptosis.
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- Pureza: 99.90%
- No. CAS: 138946-42-6
- Fòrmula: C7H2D3NO4
- Peso molecular:170.14
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Quinolinic acid-d3
MoreVer todos los productos específicos de isoformas iGluR
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Actividad biológica
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NMDA Receptor |
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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No. CAS 138946-42-6
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Unlabeled Cas 89-00-9
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Appearance Solid
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Peso molecular 170.14
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Fòrmula C7H2D3NO4
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Color White to off-white
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SMILES
[2H]C1=C([2H])C([2H])=C(C(O)=O)C(C(O)=O)=N1
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (2)
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Journal Impact Factor
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Most Recent
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Redox Biol
Reprogramming of the kynurenine pathway impairs NAD+ homeostasis and mediates doxorubicin-induced cardiotoxicity in mice. [Abstract]2025 Dec 6:89:103957. PMID: 41389767 -
Metabolites
LC-MS/MS Detection of Tryptophan, Kynurenine, Kynurenic Acid, and Quinolinic Acid in Urine Samples from Drug-Positive and Illicit Drug-Negative Patients with a Known History of Substance Use Disorder. [Abstract]2025 Nov 18;15(11):749. PMID: 41295333
Solvente y solubilidad
DMSO : 33.33 mg/mL (195.90 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 3.33 mg/mL (19.57 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (251 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instrucciones de manejo (2659 KB)
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 5.8775 mL | 29.3876 mL | 58.7751 mL | 146.9378 mL |
| 5 mM | 1.1755 mL | 5.8775 mL | 11.7550 mL | 29.3876 mL | |
| 10 mM | 0.5878 mL | 2.9388 mL | 5.8775 mL | 14.6938 mL | |
| 15 mM | 0.3918 mL | 1.9592 mL | 3.9183 mL | 9.7959 mL | |
| DMSO | 20 mM | 0.2939 mL | 1.4694 mL | 2.9388 mL | 7.3469 mL |
| 25 mM | 0.2351 mL | 1.1755 mL | 2.3510 mL | 5.8775 mL | |
| 30 mM | 0.1959 mL | 0.9796 mL | 1.9592 mL | 4.8979 mL | |
| 40 mM | 0.1469 mL | 0.7347 mL | 1.4694 mL | 3.6734 mL | |
| 50 mM | 0.1176 mL | 0.5878 mL | 1.1755 mL | 2.9388 mL | |
| 60 mM | 0.0980 mL | 0.4898 mL | 0.9796 mL | 2.4490 mL | |
| 80 mM | 0.0735 mL | 0.3673 mL | 0.7347 mL | 1.8367 mL | |
| 100 mM | 0.0588 mL | 0.2939 mL | 0.5878 mL | 1.4694 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Quinolinic acid-d3 Related Classifications
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