3-Methyl-L-histidine-d3 hydrochloride
Based on 1 publication(s) in Google Scholar
3-Methyl-L-histidine-d3 hydrochloride is the deuterium labeled 3-Methyl-L-histidine hydrochloride. 3-Methyl-L-histidine hydrochloride is an endogenous amino acid that can be found in actin and myosin.
For research use only. We do not sell to patients.
- Purity: 99.67%
- Formula: C7H9D3ClN3O2
- Molecular Weight:208.66
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Storage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) 3-Methyl-L-histidine-d3 hydrochloride
MoreAll Endogenous Metabolite Isoforms
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Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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Unlabeled Cas 368-16-1
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Appearance Solid
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Molecular Weight 208.66
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Formula C7H9D3ClN3O2
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Color White to off-white
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SMILES
OC([C@@H](N)CC1=CN=CN1C([2H])([2H])[2H])=O.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications (1)
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Journal Impact Factor
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Most Recent
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Biochem Biophys Rep
Protective effects of 3-(4-hydroxy-3-methoxyphenyl) propionic acid against dexamethasone-induced muscle atrophy: modulation of associated genes and oxidative stress in female mice. [Abstract]2026 Feb 9:45:102483. PMID: 41717078
Solvent & Solubility
DMSO : 100 mg/mL (479.25 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (275 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. White WJ, Lawrie RA. Variations in the levels of 3-methyl-l-histidine of the myosins within the bovine carcass. Meat Sci. 1985;15(3):173-81. [Content Brief]
[3]. Zhu S, et al. Microbiota-derived 3-Methyl-L-histidine mediates the proatherogenic effect of high chicken protein diet. MedComm (2020). 2025 Feb 13;6(2):e70090. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.7925 mL | 23.9624 mL | 47.9249 mL | 119.8121 mL |
| 5 mM | 0.9585 mL | 4.7925 mL | 9.5850 mL | 23.9624 mL | |
| 10 mM | 0.4792 mL | 2.3962 mL | 4.7925 mL | 11.9812 mL | |
| 15 mM | 0.3195 mL | 1.5975 mL | 3.1950 mL | 7.9875 mL | |
| 20 mM | 0.2396 mL | 1.1981 mL | 2.3962 mL | 5.9906 mL | |
| 25 mM | 0.1917 mL | 0.9585 mL | 1.9170 mL | 4.7925 mL | |
| 30 mM | 0.1597 mL | 0.7987 mL | 1.5975 mL | 3.9937 mL | |
| 40 mM | 0.1198 mL | 0.5991 mL | 1.1981 mL | 2.9953 mL | |
| 50 mM | 0.0958 mL | 0.4792 mL | 0.9585 mL | 2.3962 mL | |
| 60 mM | 0.0799 mL | 0.3994 mL | 0.7987 mL | 1.9969 mL | |
| 80 mM | 0.0599 mL | 0.2995 mL | 0.5991 mL | 1.4977 mL | |
| 100 mM | 0.0479 mL | 0.2396 mL | 0.4792 mL | 1.1981 mL |
3-Methyl-L-histidine-d3 hydrochloride Related Classifications
HY-W017007SA Related Classifications
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