3-Methyl-L-histidine-d₃ hydrochloride

Name: 3-Methyl-L-histidine-d 3 hydrochloride
Brand: MedChemExpress
SKU: HY-W017007SA
Rating: 4.5 (1 reviews)

Cat. No.: HY-W017007SA: FAQs
Data Sheet Handling Instructions

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3-Methyl-L-histidine-d₃ hydrochloride is the deuterium labeled 3-Methyl-L-histidine hydrochloride. 3-Methyl-L-histidine hydrochloride can be found in actin and myosin and is a derivative of histidine.

For research use only. We do not sell to patients.

3-Methyl-L-histidine-d<sub>3</sub> hydrochloride Chemical Structure

3-Methyl-L-histidine-d₃ hydrochloride Chemical Structure

Size	Price	Stock	Quantity
1 mg	USD 580	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 2050	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 3520	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of 3-Methyl-L-histidine-d₃ hydrochloride:

3-Methyl-L-histidine In-stock
3-Methyl-D-histidine-d₃ hydrochloride In-stock
3-Methyl-L-histidine-d₃ Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

208.66

Formula

C₇H₉D₃ClN₃O₂

Appearance

Solid

Color

White to off-white

SMILES

OC([C@@H](N)CC1=CN=CN1C([2H])([2H])[2H])=O.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (479.25 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.7925 mL	23.9624 mL	47.9249 mL
5 mM	0.9585 mL	4.7925 mL	9.5850 mL
10 mM	0.4792 mL	2.3962 mL	4.7925 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
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μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. White WJ, Lawrie RA. Variations in the levels of 3-methyl-l-histidine of the myosins within the bovine carcass. Meat Sci. 1985;15(3):173-81. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	4.7925 mL	23.9624 mL	47.9249 mL	119.8121 mL
	5 mM	0.9585 mL	4.7925 mL	9.5850 mL	23.9624 mL
	10 mM	0.4792 mL	2.3962 mL	4.7925 mL	11.9812 mL
	15 mM	0.3195 mL	1.5975 mL	3.1950 mL	7.9875 mL
	20 mM	0.2396 mL	1.1981 mL	2.3962 mL	5.9906 mL
	25 mM	0.1917 mL	0.9585 mL	1.9170 mL	4.7925 mL
	30 mM	0.1597 mL	0.7987 mL	1.5975 mL	3.9937 mL
	40 mM	0.1198 mL	0.5991 mL	1.1981 mL	2.9953 mL
	50 mM	0.0958 mL	0.4792 mL	0.9585 mL	2.3962 mL
	60 mM	0.0799 mL	0.3994 mL	0.7987 mL	1.9969 mL
	80 mM	0.0599 mL	0.2995 mL	0.5991 mL	1.4977 mL
	100 mM	0.0479 mL	0.2396 mL	0.4792 mL	1.1981 mL