Amino-PEG3-2G degrader-1 hydrochloride

Cat. No.: HY-158985A Pureté: 99.04%: Fiche technique
COA

SDS
Instruction de manipulation
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Amino-PEG3-2G degrader-1 hydrochloride is the hydrochloride salt form of Amino-PEG3-2G degrader-1 (HY-158985). Amino-PEG3-2G degrader-1 hydrochloride is a conjugate of a PEG Linker and a pyrazole-linked FBnG tag for ubiquitin-proteasome system (UPS) induction. Amino-PEG3-2G degrader-1 hydrochloride can be used to synthesize autophagy-targeting chimeras (AUTACs).

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Amino-PEG3-2G degrader-1 hydrochloride Chemical Structure

Size	Stock	Quantité
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	En stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	En stock	Estimated Time of Arrival: December 31
Solid
5 mg	En stock	Estimated Time of Arrival: December 31
10 mg	En stock	Estimated Time of Arrival: December 31
25 mg	En stock	Estimated Time of Arrival: December 31
50 mg	En stock	Estimated Time of Arrival: December 31
100 mg	En stock	Estimated Time of Arrival: December 31
200 mg	Obtenir un devis
500 mg	Obtenir un devis

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Other Forms of Amino-PEG3-2G degrader-1 hydrochloride:

Amino-PEG3-2G degrader-1 Obtenir un devis

Recommandations en vedette

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Activité biologique
Pureté et documentation
Références
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Description

Masse moléculaire

565.04

Formule

C₂₅H₃₄ClFN₈O₄

Appearance

Solid

Color

White to off-white

SMILES

O=C1N=C(NC2=C1N=C(N2CC3=CC=C(C=C3)F)C4=CN(CCCOCCOCCOCCCN)N=C4)N.Cl

Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvant et solubilité

In Vitro:

DMSO : 100 mg/mL (176.98 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.7698 mL	8.8489 mL	17.6979 mL
5 mM	0.3540 mL	1.7698 mL	3.5396 mL
10 mM	0.1770 mL	0.8849 mL	1.7698 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Pureté et documentation

Purity: 99.04%

Select Batch:

Fiche technique (266 KB) SDS (252 KB)

COA (245 KB) HNMR (352 KB) RP-HPLC (250 KB) LCMS (98 KB)

Instruction de manipulation (2659 KB)

Références

[1]. Takahashi D, et al. Second-Generation AUTACs for Targeted Autophagic Degradation. J Med Chem. 2023 Sep 14;66(17):12342-12372. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.7698 mL	8.8489 mL	17.6979 mL	44.2447 mL
	5 mM	0.3540 mL	1.7698 mL	3.5396 mL	8.8489 mL
	10 mM	0.1770 mL	0.8849 mL	1.7698 mL	4.4245 mL
	15 mM	0.1180 mL	0.5899 mL	1.1799 mL	2.9496 mL
	20 mM	0.0885 mL	0.4424 mL	0.8849 mL	2.2122 mL
	25 mM	0.0708 mL	0.3540 mL	0.7079 mL	1.7698 mL
	30 mM	0.0590 mL	0.2950 mL	0.5899 mL	1.4748 mL
	40 mM	0.0442 mL	0.2212 mL	0.4424 mL	1.1061 mL
	50 mM	0.0354 mL	0.1770 mL	0.3540 mL	0.8849 mL
	60 mM	0.0295 mL	0.1475 mL	0.2950 mL	0.7374 mL
	80 mM	0.0221 mL	0.1106 mL	0.2212 mL	0.5531 mL
	100 mM	0.0177 mL	0.0885 mL	0.1770 mL	0.4424 mL