HaloAUTAC tt15
Based on 1 Customer Validation
HaloAUTAC tt15 is an autophagy-targeting chimera (AUTAC), that targets the Halo Tag carrying proteins, and degrades via the autophagy mechanism.
For research use only. We do not sell to patients.
- Purity: 96.28%
- CAS No.: 2241668-45-9
- Formula: C33H49Cl2N7O8S
- Molecular Weight:774.76
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
HaloAUTAC tt15 (1 μM, 24 h) degrades EGFP-HT protein (enhanced green fluorescence protein-fused HaloTag) in HeLa cell[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2241668-45-9
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Appearance Solid
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Molecular Weight 774.76
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Formula C33H49Cl2N7O8S
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Color White to light yellow
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SMILES
ClCCCCCCOCCOCCOCCOCCOCCNC([C@@H](NC(C)=O)CSC1=NC(C(N=C(N2)N)=O)=C2N1CC3=CC=C(C=C3)Cl)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (129.07 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (266 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.2907 mL | 6.4536 mL | 12.9072 mL | 32.2681 mL |
| 5 mM | 0.2581 mL | 1.2907 mL | 2.5814 mL | 6.4536 mL | |
| 10 mM | 0.1291 mL | 0.6454 mL | 1.2907 mL | 3.2268 mL | |
| 15 mM | 0.0860 mL | 0.4302 mL | 0.8605 mL | 2.1512 mL | |
| 20 mM | 0.0645 mL | 0.3227 mL | 0.6454 mL | 1.6134 mL | |
| 25 mM | 0.0516 mL | 0.2581 mL | 0.5163 mL | 1.2907 mL | |
| 30 mM | 0.0430 mL | 0.2151 mL | 0.4302 mL | 1.0756 mL | |
| 40 mM | 0.0323 mL | 0.1613 mL | 0.3227 mL | 0.8067 mL | |
| 50 mM | 0.0258 mL | 0.1291 mL | 0.2581 mL | 0.6454 mL | |
| 60 mM | 0.0215 mL | 0.1076 mL | 0.2151 mL | 0.5378 mL | |
| 80 mM | 0.0161 mL | 0.0807 mL | 0.1613 mL | 0.4034 mL | |
| 100 mM | 0.0129 mL | 0.0645 mL | 0.1291 mL | 0.3227 mL |
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