2241669-09-8
Chemical Structure
AUTAC1
- CAS No.: 2241669-09-8
- Formula:C44H63FN8O11S
- Molecular Weight:931.08
IUPAC Name: (3R,4S,5S,6R)-5-methoxy-4-((2R,3R)-2-methyl-3-(3-methylbut-2-en-1-yl)oxiran-2-yl)-1-oxaspiro[2.5]octan-6-yl ((R)-4-(((2-amino-9-(4-fluorobenzyl)-6-oxo-6,9-dihydro-1H-purin-8-yl)thio)methyl)-2,5-dioxo-10,13,16-trioxa-3,6-diazanonadecan-19-yl)carbamate
InChIKey: HZYVWSXXYHBZTO-KDJNBPRZSA-N
SMILES: CO[C@H]1[C@@]([C@]([C@H]2C/C=C(C)\C)(O2)C)([H])[C@@]3(CO3)CC[C@H]1OC(NCCCOCCOCCOCCCNC([C@@H](NC(C)=O)CSC4=NC5=C(N=C(N)NC5=O)N4CC6=CC=C(F)C=C6)=O)=O
Biological Activity: AUTAC1 is a MetAP2-targeting autophagy-mediated degrader (AUTAC). AUTACs contain a degradation tag and a warhead to provide target specificity. AUTAC1 contains an FBnG (p-Fluorobenzyl Guanine) and a Fumagillol moiety. Fumagillol binds covalently to MetAP2[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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AUTAC1 | 95.0% | AUTAC1 is a MetAP2-targeting autophagy-mediated degrader (AUTAC). AUTACs contain a degradation tag and a warhead to provide target specificity. AUTAC1 contains an FBnG (p-Fluorobenzyl Guanine) and a Fumagillol moiety. Fumagillol binds covalently to MetAP2. | ||||||||||||||||||||
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Keywords
