1. Autophagy
  2. Autophagy
  3. AUTAC1

AUTAC1 

Cat. No.: HY-134183
Handling Instructions

AUTAC1 is a MetAP2-targeting autophagy-mediated degrader (AUTAC). AUTACs contain a degradation tag and a warhead to provide target specificity. AUTAC1 contains an FBnG (p-Fluorobenzyl Guanine) and a Fumagillol moiety. Fumagillol binds covalently to MetAP2.

For research use only. We do not sell to patients.

AUTAC1 Chemical Structure

AUTAC1 Chemical Structure

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Description

AUTAC1 is a MetAP2-targeting autophagy-mediated degrader (AUTAC). AUTACs contain a degradation tag and a warhead to provide target specificity. AUTAC1 contains an FBnG (p-Fluorobenzyl Guanine) and a Fumagillol moiety. Fumagillol binds covalently to MetAP2[1].

In Vitro

AUTAC1 (1-100 μM, 24 h) silences endogenous MetAP2 in hela cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: HeLa cells.
Concentration: 1-100 μM.
Incubation Time: 24 h.
Result: Silenced endogenous MetAP2.
Molecular Weight

931.08

Formula

C₄₄H₆₃FN₈O₁₁S

SMILES

CO[[email protected]]1C([[email protected]]([[email protected]]2C/C=C(C)\C)(O2)C)[[email protected]@]3(CO3)CC[[email protected]]1OC(NCCCOCCOCCOCCCNC([[email protected]@H](NC(C)=O)CSC4=NC5=C(N=C(N)NC5=O)N4CC6=CC=C(F)C=C6)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

AUTAC1AUTAC 1AUTAC-1AutophagyDebrisautophagyAUTACLC3BInhibitorinhibitorinhibit

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AUTAC1
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HY-134183
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