1. Autophagy
  2. Autophagy
  3. AUTAC2

AUTAC2 

Cat. No.: HY-134184
Handling Instructions

AUTAC2 is a FKBP12-targeting autophagy-mediated degrader (AUTAC). AUTAC2 contains an FBnG (p-Fluorobenzyl Guanine) and an SLF (c ligand of FKBP) moiety. SLF binds non-covalently to FKBP12.

For research use only. We do not sell to patients.

AUTAC2 Chemical Structure

AUTAC2 Chemical Structure

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Description

AUTAC2 is a FKBP12-targeting autophagy-mediated degrader (AUTAC). AUTAC2 contains an FBnG (p-Fluorobenzyl Guanine) and an SLF (c ligand of FKBP) moiety. SLF binds non-covalently to FKBP12[1].

In Vitro

AUTAC1 (1-100 μM, 24 h) silences endogenous FKBP12 in hela cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: HeLa cells.
Concentration: 0-100 μM.
Incubation Time: 24 h.
Result: Silenced endogenous FKBP12.
Molecular Weight

1229.42

Formula

C₆₁H₈₁FN₁₀O₁₄S

SMILES

O=C([[email protected]@H](NC(C)=O)CSC1=NC2=C(N=C(N)NC2=O)N1CC3=CC=C(F)C=C3)NCCCOCCOCCOCCCNC(CCC(NC4=CC=CC([[email protected]@H](CCC5=CC=C(OC)C(OC)=C5)OC([[email protected]@H]6CCCCN6C(C(C(C)(CC)C)=O)=O)=O)=C4)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

AUTAC2AUTAC 2AUTAC-2AutophagyLC3Bp62SQSTM-1AUTACcGMPInhibitorinhibitorinhibit

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AUTAC2
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