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TBK1/IKKε-IN-5 

Cat. No.: HY-128679 Purity: 99.80%
Handling Instructions

TBK1/IKKε-IN-5 (compound 1) is a dual TBK1 and IKKε inhibitor, with IC50 values of 1 nM and 5.6 nM for TBK1 and IKKε, respectively.

For research use only. We do not sell to patients.

TBK1/IKKε-IN-5 Chemical Structure

TBK1/IKKε-IN-5 Chemical Structure

CAS No. : 1893397-65-3

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 1107 In-stock
Estimated Time of Arrival: December 31
1 mg USD 550 In-stock
Estimated Time of Arrival: December 31
5 mg USD 980 In-stock
Estimated Time of Arrival: December 31
10 mg USD 1500 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

* Please select Quantity before adding items.

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Based on 1 publication(s) in Google Scholar

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Description

TBK1/IKKε-IN-5 (compound 1) is a dual TBK1 and IKKε inhibitor, with IC50 values of 1 nM and 5.6 nM for TBK1 and IKKε, respectively[1].

IC50 & Target

IC50: 1 nM (TBK1), 5.6 nM (IKKε)[1].

Molecular Weight

513.59

Formula

C₂₈H₃₁N₇O₃

CAS No.

1893397-65-3

SMILES

N#CC1=CC(C2=NC(NC3=CC=C(N4CCN(C5COC5)CC4)C=C3)=NC=N2)=CC=C1OC6CCOCC6

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 7.81 mg/mL (15.21 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9471 mL 9.7354 mL 19.4708 mL
5 mM 0.3894 mL 1.9471 mL 3.8942 mL
10 mM 0.1947 mL 0.9735 mL 1.9471 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ mg/mL; Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.80%

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Product Name:
TBK1/IKKε-IN-5
Cat. No.:
HY-128679
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