EphA10

EphA10 is one of the most recently annotated Eph receptors and remains poorly characterized; the family numbering skips EphA9, which is absent from the human genome. EphA10 contains the canonical Eph architecture of an ephrin-binding domain, a cysteine-rich region, two fibronectin type III repeats and a tyrosine kinase domain, and its expression has been detected in reproductive tissues, kidney, liver and colon. Preferred ephrin ligands and physiological functions have not been firmly established, though roles in tissue homeostasis and in some tumors have been proposed. Recombinant EphA10 enables ligand-screening and kinase-profiling studies of this enigmatic family member.