2937327-93-8
2937327-93-8
Chemical Structure
BI-2865
- CAS No.: 2937327-93-8
- Formula:C23H27N7O2S
- Molecular Weight:465.57
InChIKey: MIUFORKWYHBPRW-HMFCALDFSA-N
SMILES: N#CC1=C(N)SC2=C1[C@@](C)(C3=NC(C4=NC(O[C@@H](C)[C@@H]5CCCN5C)=CC=N4)=NO3)CCC2
Biological Activity: BI-2865 is a none-covalent pan-KRAS Inhibitor. BI-2865 binds to WT, G12C, G12D, G12V and G13D mutant KRAS with KDs of 6.9, 4.5, 32, 26, 4.3 nM respectively. BI-2865 inhibits the proliferation of G12C, G12D or G12V mutant KRAS expressing BaF3 cells (mean IC50: roughly 140 nM)[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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BI-2865 | 99.16% | BI-2865 is a none-covalent pan-KRAS Inhibitor. BI-2865 binds to WT, G12C, G12D, G12V and G13D mutant KRAS with KDs of 6.9, 4.5, 32, 26, 4.3 nM respectively. BI-2865 inhibits the proliferation of G12C, G12D or G12V mutant KRAS expressing BaF3 cells (mean IC50: roughly 140 nM). | ||||||||||||||||||||
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BI-2865 (Standard) | ≥98% | BI-2865 (Standard) is the analytical standard of BI-2865 (HY-153724). This product is intended for research and analytical applications. BI-2865 is a none-covalent pan-KRAS Inhibitor. BI-2865 binds to WT, G12C, G12D, G12V and G13D mutant KRAS with KDs of 6.9, 4.5, 32, 26, 4.3 nM respectively. BI-2865 inhibits the proliferation of G12C, G12D or G12V mutant KRAS expressing BaF3 cells (mean IC50: roughly 140 nM). | ||||||||||||||||||||
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