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  3. ML141

ML141 (Synonyms: CID-2950007)

Cat. No.: HY-12755 Purity: 99.21%
Handling Instructions

ML141 (CID-2950007) is a potent, allosteric,selective and reversible non-competitive inhibitor of Cdc42 GTPase. ML141 inhibits Cdc42 wild type and Cdc42 Q61L mutant with EC50s of 2.1 and 2.6 μM, respectively. ML141 shows low micromolar potency and selectivity against other members of the Rho family of GTPases (Rac1, Rab2, Rab7). ML141 do not show cytotoxicity in multiple cell lines.

For research use only. We do not sell to patients.

ML141 Chemical Structure

ML141 Chemical Structure

CAS No. : 71203-35-5

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 92 In-stock
Estimated Time of Arrival: December 31
5 mg USD 84 In-stock
Estimated Time of Arrival: December 31
10 mg USD 150 In-stock
Estimated Time of Arrival: December 31
50 mg USD 540 In-stock
Estimated Time of Arrival: December 31
100 mg USD 864 In-stock
Estimated Time of Arrival: December 31
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Description

ML141 (CID-2950007) is a potent, allosteric,selective and reversible non-competitive inhibitor of Cdc42 GTPase. ML141 inhibits Cdc42 wild type and Cdc42 Q61L mutant with EC50s of 2.1 and 2.6 μM, respectively. ML141 shows low micromolar potency and selectivity against other members of the Rho family of GTPases (Rac1, Rab2, Rab7). ML141 do not show cytotoxicity in multiple cell lines[1][2].

In Vitro

ML141 (CID-2950007) is not cytotoxic in either cell line at doses of 0.1-3 μM after treatment for 4 days. OVCA429 cells were insensitive to 10 μM compound, whereas some cytotoxicity was observed in SKOV3ip cells at this concentration after a 4-day treatment, although it did not reach statistical significance. ML141 is not cytotoxic toward Swiss 3T3 or Vero E6 cells up to 10 μM for 24 and 48 h, respectively[1].
ML141 inhibits 3T3 fibroblast filopodia formation, and inhibits ovarian cancer cell migration[1].

In Vivo

ML141 (CID-2950007) (10 µM; intracerebroventricular injection) causes acute anxiety in mice[3].

Animal Model: C57Bl/6J mice[3]
Dosage: 10 µM
Administration: Intracerebroventricular injection
Result: Increased anxiety in mice.
Molecular Weight

407.49

Formula

C₂₂H₂₁N₃O₃S

CAS No.

71203-35-5

SMILES

O=S(C1=CC=C(N2N=C(C3=CC=CC=C3)CC2C4=CC=C(OC)C=C4)C=C1)(N)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 55 mg/mL (134.97 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4540 mL 12.2702 mL 24.5405 mL
5 mM 0.4908 mL 2.4540 mL 4.9081 mL
10 mM 0.2454 mL 1.2270 mL 2.4540 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (6.14 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (6.14 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (6.14 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

ML141CID-2950007ML 141ML-141CID2950007CID 2950007RasApoptosistoxicitynoncompetitiveallostericovariancanceracuteanxietyOVCA429cellsInhibitorinhibitorinhibit

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ML141
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HY-12755
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