2. Stem Cell/Wnt Apoptosis
  3. Hedgehog Smo Gli Apoptosis
  4. TPB15

TPB15 is an orally active and potent Hh (Hedgehog) signaling inhibitor. TPB15 markedly induces cell cycle arrest and apoptosis in MDA-MB-468 cells. TPB15 blocks Smo (Smoothened) translocation into the cilia and reduced Smo protein and mRNA expression. TPB15 inhibits the expression of the downstream regulatory factor glioma-associated oncogene 1 (Gli1). TPB15 shows good anti-tumor activity with low toxicity.

For research use only. We do not sell to patients.

TPB15 Chemical Structure

TPB15 Chemical Structure

CAS No. : 2170347-69-8

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TPB15 Related Antibodies

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Description

TPB15 is an orally active and potent Hh (Hedgehog) signaling inhibitor. TPB15 markedly induces cell cycle arrest and apoptosis in MDA-MB-468 cells. TPB15 blocks Smo (Smoothened) translocation into the cilia and reduced Smo protein and mRNA expression. TPB15 inhibits the expression of the downstream regulatory factor glioma-associated oncogene 1 (Gli1). TPB15 shows good anti-tumor activity with low toxicity[1].

Molecular Weight

453.11

Formula

C18H9Cl4N5O
CAS No.
SMILES

O=C(C1=C(N=C(C=C1)Cl)Cl)NC2=CC(C3=NN=C4C(Cl)=CC=CN43)=C(C=C2)Cl
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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TPB15 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TPB152170347-69-8TPB 15TPB-15HedgehogSmoGliApoptosisSmoothenedMDA-MB-468 cells,Hedgehog pathwaysmoothened inhibitortriple-negative breast cancergliomaanti-tumor activityInhibitorinhibitorinhibit

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