2. Signaling Pathways
  3. Stem Cell/Wnt
  4. Gli
  5. Gli Inhibitor

Gli Inhibitor

Gli Inhibitors (3):

Cat. No. Product Name Effect Purity
  • HY-13901
    GANT 61
    		Inhibitor ≥98.0%
    GANT 61 is an inhibitor of Gli1 and Gli2 targeting the Hedgehog/GLI pathway.
  • HY-122590
    Glabrescione B
    		Inhibitor 98.05%
    Glabrescione B is the first compound that binds the Hedgehog (Hh) modulator Gli1. Glabrescione B impairs its activity by interfering with Gli1-DNA interaction. Glabrescione B inhibits the growth of Hedgehog-dependent tumor cells, the self-renewal ability, and clonogenicity of tumor-derived stem cells.
  • HY-147670
    TPB15
    		Inhibitor
    TPB15 is an orally active and potent Hh (Hedgehog) signaling inhibitor. TPB15 markedly induces cell cycle arrest and apoptosis in MDA-MB-468 cells. TPB15 blocks Smo (Smoothened) translocation into the cilia and reduced Smo protein and mRNA expression. TPB15 inhibits the expression of the downstream regulatory factor glioma-associated oncogene 1 (Gli1). TPB15 shows good anti-tumor activity with low toxicity.