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Art. -Nr.: HY-184494

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GLI-IN-1

GLI-IN-1 is a potent, PKC-dependent Gli inhibitor. GLI-IN-1 binds to the C1 domain of PKC, forms hydrogen-bonding interactions with the M239 residue, and mediates the inhibition of downstream Gli via a PKC-mediated, Smoothened-independent mechanism. GLI-IN-1 can be used in studies of Gli-driven cancers and osteogenic differentiation.

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Formel: C₃₃H₅₅N₃O₃
Molecular Weight:541.81

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

GLI-IN-1 Chemical Structure

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Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Reinheit & Dokumentation
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Calculators
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Biologische Aktivität

Beschreibung

Alle PKC Isoform-spezifische Produkte anzeigen :

In Vitro

GLI-IN-1 (Compound 7e) (30 h) potently inhibits the Smo-dependent Gli signaling pathway in Shh-LIGHT2 cells, with an IC₅₀ value of 21 nM^[1].
GLI-IN-1 (30 h) potently inhibits the Smo-independent constitutive Gli signaling pathway in Sufu-KO-LIGHT cells, with an IC₅₀ of 24 nM^[1].
GLI-IN-1 potently inhibits Gli-dependent osteogenic differentiation in C3H10T1/2 mesenchymal stem cells, with an IC₅₀ of 22 nM^[1].
GLI-IN-1 shows no detectable cytotoxicity in Shh-LIGHT2, Sufu-KO-LIGHT and C3H10T1/2 cells, with a CC₅₀ >5000 nM^[1].
GLI-IN-1 exhibits favorable metabolic stability in liver microsomes, with an intrinsic clearance rate of 3.2 μL min⁻¹ mg⁻¹^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 541.81
Formel C₃₃H₅₅N₃O₃
SMILES

CCCCCCCC/C=C\CCCCCCCC(NC1=CC(C[C@@H](CO)NC([C@H](C(C)C)N2C)=O)=C2C=C1)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Haddad M, et al. Design of PKC-Targeting Benzolactams as Gli Inhibitors[J]. ACS Medicinal Chemistry Letters, 2026.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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GLI-IN-1

Alle PKC Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

GLI-IN-1 Related Classifications

HY-184494 Related Classifications