1. Stem Cell/Wnt
  2. Gli
  3. Glabrescione B

Glabrescione B 

Cat. No.: HY-122590
Handling Instructions

Glabrescione B is the first compound that binds the Hedgehog (Hh) modulator Gli1. Glabrescione B impairs its activity by interfering with Gli1-DNA interaction. Glabrescione B inhibits the growth of Hedgehog-dependent tumor cells, the self-renewal ability, and clonogenicity of tumor-derived stem cells.

For research use only. We do not sell to patients.

Glabrescione B Chemical Structure

Glabrescione B Chemical Structure

CAS No. : 65893-94-9

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Description

Glabrescione B is the first compound that binds the Hedgehog (Hh) modulator Gli1. Glabrescione B impairs its activity by interfering with Gli1-DNA interaction. Glabrescione B inhibits the growth of Hedgehog-dependent tumor cells, the self-renewal ability, and clonogenicity of tumor-derived stem cells[1][2].

IC50 & Target

Gli1-DNA Interaction[1]

In Vitro

Glabrescione B (5 μM; 24-72 hours) inhibits the growth of Gli-dependent basal cell carcinoma[2].
Glabrescione B (1-10 μM; 24-48 hours) decreases Gli1 mRNA expression levels[2].

Cell Proliferation Assay[1]

Cell Line: ASZ001 BCC cells
Concentration: 5 μM
Incubation Time: 24-72 hours
Result: Basal cell carcinoma cell proliferation was impaired.

Western Blot Analysis[1]

Cell Line: ASZ001 BCC cells
Concentration: 1-10 μM
Incubation Time: 24-48 hours
Result: Gli1 mRNA expression levels was decreased.
In Vivo
Animal Model: Female NOD/SCID mice (ASZ001 BCC allografts)[2]
Dosage: 100 μmol/kg
Administration: I.p.; every second day for 18 days
Result: A significant reduction of tumor growth as well as Gli1 mRNA levels was observed.
Molecular Weight

450.52

Formula

C₂₇H₃₀O₆

CAS No.

65893-94-9

SMILES

O=C1C(C2=CC=C(OC/C=C(C)/C)C(OC/C=C(C)/C)=C2)=COC3=CC(OC)=CC(OC)=C13

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Glabrescione BGlitumorGli1DNAinteractioncancerstemcellsbasalcarcinomaInhibitorinhibitorinhibit

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