65893-94-9
Chemical Structure
Glabrescione B
- CAS No.: 65893-94-9
- Formula:C27H30O6
- Molecular Weight:450.52
IUPAC Name: 3-(3,4-bis((3-methylbut-2-en-1-yl)oxy)phenyl)-5,7-dimethoxy-4H-chromen-4-one
InChIKey: RHXDATRKLOYVTC-UHFFFAOYSA-N
SMILES: O=C1C(C2=CC=C(OC/C=C(C)/C)C(OC/C=C(C)/C)=C2)=COC3=CC(OC)=CC(OC)=C13
Biological Activity: Glabrescione B is the first compound that binds the Hedgehog (Hh) modulator Gli1. Glabrescione B impairs its activity by interfering with Gli1-DNA interaction. Glabrescione B inhibits the growth of Hedgehog-dependent tumor cells, the self-renewal ability, and clonogenicity of tumor-derived stem cells[1][2].
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Glabrescione B | 98.08% | Glabrescione B is the first compound that binds the Hedgehog (Hh) modulator Gli1. Glabrescione B impairs its activity by interfering with Gli1-DNA interaction. Glabrescione B inhibits the growth of Hedgehog-dependent tumor cells, the self-renewal ability, and clonogenicity of tumor-derived stem cells. | ||||||||||||||||||||
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- [1]. Ingallina C, et al. Polymeric glabrescione B nanocapsules for passive targeting of Hedgehog-dependent tumor therapy in vitro. Nanomedicine (Lond). 2017;12(7):711-728. [Content Brief]
- [2]. Infante P, et al. Gli1/DNA interaction is a druggable target for Hedgehog-dependent tumors. EMBO J. 2015;34(2):200-217. [Content Brief]
Keywords
