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Pratensein 

Cat. No.: HY-N7981
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Pratensein, a flavonoid, ameliorates β-amyloid-induced cognitive impairment in rats via reducing oxidative damage and restoring synapse and BDNF levels.

For research use only. We do not sell to patients.

Pratensein Chemical Structure

Pratensein Chemical Structure

CAS No. : 2284-31-3

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Description

Pratensein, a flavonoid, ameliorates β-amyloid-induced cognitive impairment in rats via reducing oxidative damage and restoring synapse and BDNF levels[1].

In Vivo

Pratensein significantly attenuates neuronal degeneration and apoptosis in hippocampus. The over-expression in IL-1β and TNF-α as well as the extensive astrogliosis and microgliosis in hippocampus induced by Aβ1-42 are significantly reduced following administration of Pratensein. Pratensein treatment significantly suppresses the activation of NF-κB in hippocampus. Pratensein is able to increase the levels of synaptophysin and brain-derived neurotrophic factor (BDNF)[1].
Pratensein (20 mg/kg; p.o.; once daily for 3 weeks) ameliorates learning and memory deficits in Aβ1-42 rat model of Alzheimer’s disease[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male 10-week old Wistar rats[1]
Dosage: 20 mg/kg
Administration: P.o.; once daily for 3 weeks
Result: The spatial learning and memory ability of rats was improved.
Molecular Weight

300.26

Formula

C₁₆H₁₂O₆

CAS No.
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