7,3'-Di-O-Methylorobol
7,3'-Di-O-Methylorobol is a flavone that can be isolated from Sophora japonica.
For research use only. We do not sell to patients.
- CAS No.: 104668-88-4
- Formula: C17H14O6
- Molecular Weight:314.29
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| C2C12 | IC50 |
32.47 μg/mL
Compound: 16
|
Cytotoxicity against mouse C2C12 cells assessed as reduction in cell viability by MTT assay
Cytotoxicity against mouse C2C12 cells assessed as reduction in cell viability by MTT assay
|
[PMID: 33412152] |
| Neutrophil | IC50 |
>10 μM
Compound: 4
|
Antiinflammatory activity in human neutrophils assessed as inhibition of fMLP/CB-induced elastase release pretreated for 5 mins followed by fMLP/CB stimulation using MeO-Suc-Ala-Ala-Pro-Val-p-nitroanilide as substrate
Antiinflammatory activity in human neutrophils assessed as inhibition of fMLP/CB-induced elastase release pretreated for 5 mins followed by fMLP/CB stimulation using MeO-Suc-Ala-Ala-Pro-Val-p-nitroanilide as substrate
|
[PMID: 29381070] |
| Neutrophil | IC50 |
>10 μM
Compound: 4
|
Anti-inflammatory activity in human neutrophils assessed as inhibition of fMLP/CB-induced superoxide anion generation pretreated for 5 mins followed by cytochalasin B addition for 3 mins and subsequent fMLP stimulation for 10 mins by superoxide dismutase
Anti-inflammatory activity in human neutrophils assessed as inhibition of fMLP/CB-induced superoxide anion generation pretreated for 5 mins followed by cytochalasin B addition for 3 mins and subsequent fMLP stimulation for 10 mins by superoxide dismutase
|
[PMID: 29381070] |
| RBL-2H3 | IC50 |
>100 μM
Compound: 4
|
Antiallergic activity in anti-DNP IgE-sensitized rat RBL2H3 cells assessed as inhibition of DNP-BSA-induced beta hexosaminidase release pretreated for 10 mins followed by DNP-BSA addition measured after 10 mins by p-NAG substrate based assay
Antiallergic activity in anti-DNP IgE-sensitized rat RBL2H3 cells assessed as inhibition of DNP-BSA-induced beta hexosaminidase release pretreated for 10 mins followed by DNP-BSA addition measured after 10 mins by p-NAG substrate based assay
|
[PMID: 29381070] |
Chemical Information
-
CAS No. 104668-88-4
-
Molecular Weight 314.29
-
Formula C17H14O6
-
SMILES
O=C1C(C2=CC=C(O)C(OC)=C2)=COC3=CC(OC)=CC(O)=C13
-
Structure Classification
-
Initial Source
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)