Hedgehog IN-9
Hedgehog IN-9 (Compound 1) is a Hedgehog inhibitor. Hedgehog IN-9 prevents GLI1 expression and enhances cellular BRD2 protein levels. Hedgehog IN-9 inhibits growth of medulloblastoma spheroid cells and can be used for synthesis of photoaffinity labeling probe.
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- CAS No.: 438488-95-0
- Formule: C19H22N2O3S
- Masse moléculaire:358.45
-
Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Activité biologique
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HL-60 | IC50 |
2.01 μM
Compound: 28
|
Antiproliferative activity against human HL60 cells after 72 hrs by CCK8 assay
Antiproliferative activity against human HL60 cells after 72 hrs by CCK8 assay
|
[PMID: 26731490] |
| HT-29 | IC50 |
8.5 μM
Compound: 28
|
Antiproliferative activity against human HT-29 cells after 72 hrs by CCK8 assay
Antiproliferative activity against human HT-29 cells after 72 hrs by CCK8 assay
|
[PMID: 26731490] |
| MV4-11 | IC50 |
3.46 μM
Compound: 28
|
Antiproliferative activity against human MV4-11 cells after 72 hrs by CCK8 assay
Antiproliferative activity against human MV4-11 cells after 72 hrs by CCK8 assay
|
[PMID: 26731490] |
Chemical Information
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CAS No. 438488-95-0
-
Masse moléculaire 358.45
-
Formule C19H22N2O3S
-
SMILES
CCN1C(C2=C3C(C(S(=O)(NC4CCCCC4)=O)=CC=C31)=CC=C2)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)