2. Stem Cell/Wnt
  3. Gli
  4. GLI antagonist-1

GLI antagonist-1 is a potent GLI antagonist with an IC50 value of 1.1 µM. GLI antagonist-1 shows anti-proliferative activity. GLI antagonist-1 decreases the GLI1 mRNA expression. GLI antagonist-1 inhibits colony formation in a dose-dependent manner.

For research use only. We do not sell to patients.

GLI antagonist-1 Chemical Structure

GLI antagonist-1 Chemical Structure

CAS No. : 599150-20-6

Size Price Stock Quantity
1 mg USD 50 In-stock
5 mg USD 115 In-stock
10 mg   Get quote  
50 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

GLI antagonist-1 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

GLI antagonist-1 is a potent GLI antagonist with an IC50 value of 1.1 µM. GLI antagonist-1 shows anti-proliferative activity. GLI antagonist-1 decreases the GLI1 mRNA expression. GLI antagonist-1 inhibits colony formation in a dose-dependent manner[1].

IC50 & Target

IC50: 1.1 µM (GLI)[1]
In Vitro

GLI antagonist-1 (compound HPI-1) (0-25 µM; 72 h) shows anti-proliferative activity with IC50 values of 29, >25, 20.5 µM for SUM149, MDA-MB-231, SUM159 cells, respectively[1].
GLI antagonist-1 (10 µM; 72 h) decreases the GLI1 mRNA expression in SUM149 cells[1].
GLI antagonist-1 (5, 10, 20 µM) inhibits colony formation in a dose-dependent manner in SUM149 and MDA-MB-231 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

GLI antagonist-1 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: SUM149, MDA-MB-231, SUM159 cells
Concentration: 0-25 µM
Incubation Time: 72 h
Result: Showed anti-proliferative activity with IC50 values of 29, >25, 20.5 µM for SUM149, MDA-MB-231, SUM159 cells, respectively.
Molecular Weight

463.52

Formula

C27H29NO6
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

COCCOC(C1=C(C)NC(CC(C2=C(C=CC=C2)OC)CC3=O)=C3C1C4=CC(O)=CC=C4)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation

Purity: ≥95%

COA (250 KB) LCMS (85 KB)

Handling Instructions (2659 KB)
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

GLI antagonist-1 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GLI antagonist-1599150-20-6GLI antagonist1GLI antagonist 1Glianti-proliferativeGLI1 mRNAcolony formationSUM149MDA-MB-231SUM159 cellsInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
GLI antagonist-1
Cat. No.:
HY-107551
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

Request for HNMR Report

We have received your request and will respond to you as soon as possible.