KIR2DL1 Protein, Human (245a.a, HEK293, His)

KIR2DL1, found on NK cells, serves as a receptor for specific HLA-C alleles, inhibiting NK cell activity to prevent cell lysis. This regulatory function involves interactions with ARRB2 and, additionally, engages PTPN6 and PTPN11. The interaction's enhancement by ARRB2 underscores KIR2DL1's role in complex signaling networks that modulate NK cell function. KIR2DL1 Protein, Human (245a.a, HEK293, His) is the recombinant human-derived KIR2DL1 protein, expressed by HEK293 , with C-His labeled tag. The total length of KIR2DL1 Protein, Human (245a.a, HEK293, His) is 245 a.a., with molecular weight of ~45 kDa.

KIR2DL1, located on natural killer (NK) cells, acts as a receptor for specific HLA-C alleles, including w4 and w6, ultimately inhibiting NK cell activity to prevent cell lysis. This regulatory role is facilitated through interactions with ARRB2. Moreover, KIR2DL1 engages with PTPN6 and PTPN11, with the interaction being enhanced by ARRB2, further emphasizing its involvement in intricate signaling networks that modulate NK cell function.

Human

HEK293

C-His

P43626 (M1-H245)

3802  [NCBI]

Approximately 45 kDa

Greater than 90% as determined by reducing SDS-PAGE

Lyophilized powder

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.