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TGFBR3/TGF-beta RIII Protein, Human (sf9, His)

TGFBR3/TGF-beta RIII Protein is pivotal, binding to TGF-beta, indicating a potential role in capturing and presenting TGF-beta to signaling receptors. In gonadotrope cells, it acts as an inhibin A coreceptor, regulating FSH levels and impacting female fertility. Its interaction with DYNLT4 emphasizes diverse functional associations in cellular processes, suggesting a multifaceted role for TGFBR3 in cellular regulation and fertility control. TGFBR3/TGF-beta RIII Protein, Human (sf9, His) is the recombinant human-derived TGFBR3/TGF-beta RIII protein, expressed by Sf9 insect cells , with C-His labeled tag.

For research use only. We do not sell to patients.
  • Species: Human
  • Source: Sf9 insect cells
  • Storage:
    Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
  • TGFBR3/TGF-beta RIII Protein, Human (sf9, His) Product Image
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To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
  • Biological Activity
  • Technical Parameters
  • Product Properties
  • Documentation
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Biological Activity

Description

TGFBR3/TGF-beta RIII Protein is pivotal, binding to TGF-beta, indicating a potential role in capturing and presenting TGF-beta to signaling receptors. In gonadotrope cells, it acts as an inhibin A coreceptor, regulating FSH levels and impacting female fertility. Its interaction with DYNLT4 emphasizes diverse functional associations in cellular processes, suggesting a multifaceted role for TGFBR3 in cellular regulation and fertility control. TGFBR3/TGF-beta RIII Protein, Human (sf9, His) is the recombinant human-derived TGFBR3/TGF-beta RIII protein, expressed by Sf9 insect cells , with C-His labeled tag.

Background

The TGFBR3/TGF-beta RIII protein plays a pivotal role as it binds to TGF-beta, suggesting potential involvement in capturing and retaining TGF-beta for presentation to the signaling receptors, as inferred by similarity to related proteins. Particularly in gonadotrope cells, TGFBR3 acts as an inhibin A coreceptor, exerting regulatory control over follicle-stimulating hormone (FSH) levels and influencing female fertility, as indicated in relevant studies. Furthermore, TGFBR3 interacts with DYNLT4, underscoring its diverse functional associations in cellular processes.

Technical Parameters

  • Species Human
  • Source Sf9 insect cells
  • Tag C-His
  • Accession

    Q03167 (G21-G781)

  • Gene ID
    7049  [NCBI]
  • Molecular Construction
    • N-term
    • TGFBR3 (G21-G781)
      Accession # Q03167
    • His
    • C-term
  • Protein Length

    Partial Extracellular Domain

  • Synonyms

    TGFBR3; TGF-Beta Receptor Type III; Transforming Growth Factor Beta Receptor 3; TGF-Beta Receptor Type 3; Betaglycan; Betaglycan Proteoglycan; Transforming Growth Factor Beta Receptor III; TGFR-3; Transforming Growth Factor Beta Receptor Type 3; Transform

  • AA Sequence

    GPEPGALCELSPVSASHPVQALMESFTVLSGCASRGTTGLPQEVHVLNLRTAGQGPGQLQREVTLHLNPISSVHIHHKSVVFLLNSPHPLVWHLKTERLATGVSRLFLVSEGSVVQFSSANFSLTAETEERNFPHGNEHLLNWARKEYGAVTSFTELKIARNIYIKVGEDQVFPPKCNIGKNFLSLNYLAEYLQPKAAEGCVMSSQPQNEEVHIIELITPNSNPYSAFQVDITIDIRPSQEDLEVVKNLILILKCKKSVNWVIKSFDVKGSLKIIAPNSIGFGKESERSMTMTKSIRDDIPSTQGNLVKWALDNGYSPITSYTMAPVANRFHLRLENNAEEMGDEEVHTIPPELRILLDPGALPALQNPPIRGGEGQNGGLPFPFPDISRRVWNEEGEDGLPRPKDPVIPSIQLFPGLREPEEVQGSVDIALSVKCDNEKMIVAVEKDSFQASGYSGMDVTLLDPTCKAKMNGTHFVLESPLNGCGTRPRWSALDGVVYYNSIVIQVPALGDSSGWPDGYEDLESGDNGFPGDMDEGDASLFTRPEIVVFNCSLQQVRNPSSFQEQPHGNITFNMELYNTDLFLVPSQGVFSVPENGHVYVEVSVTKAEQELGFAIQTCFISPYSNPDRMSHYTIIENICPKDESVKFYSPKRVHFPIPQADMDKKRFSFVFKPVFNTSLLFLQCELTLCTKMEKHPQKLPKCVPPDEACTSLDASIIWAMMQNKKTFTKPLAVIHHEAESKEKGPSMKEPNPISPPIFHG

  • Predicted Molecular Mass

    87.8 kDa

  • Molecular Weight

    Approximately 88 kDa, based on SDS-PAGE under reducing conditions.

  • Glycosylation

    Yes

  • Purity

    ≥ 90%, as determined by reducing SDS-PAGE.

Product Properties

Appearance

Solution

Endotoxin Level

<1 EU/μg, determined by LAL method.

Storage & Stability

Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping

Shipping with dry ice.

Calculators

Reconstitution Calculator

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Dilution Calculator

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The Specific Activity Calculator Equation
  • Specific Activity (Unit/mg)
  • Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) Specific Activity (Unit/mg)
Unit/mg
= 106 ÷
Biological Activity (ED50) Biological Activity (ED50)
106 ÷
ng/mL
MOQ
Minimum order quantity
100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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