2. Recombinant Proteins
  3. Cytokines and Growth Factors Receptor Proteins Enzymes & Regulators
  4. TGF-beta Superfamily Receptor Serine/Threonine Kinases Serine/Threonine Kinase Proteins
  5. TGF-beta Receptor Type III TGF-β Receptor
  6. TGFBR3/TGF-beta RIII Protein, Human (sf9, His)

TGFBR3/TGF-beta RIII Protein, Human (sf9, His)

Cat. No.: HY-P74521
Handling Instructions

TGFBR3/TGF-beta RIII Protein is pivotal, binding to TGF-beta, indicating a potential role in capturing and presenting TGF-beta to signaling receptors. In gonadotrope cells, it acts as an inhibin A coreceptor, regulating FSH levels and impacting female fertility. Its interaction with DYNLT4 emphasizes diverse functional associations in cellular processes, suggesting a multifaceted role for TGFBR3 in cellular regulation and fertility control. TGFBR3/TGF-beta RIII Protein, Human (sf9, His) is the recombinant human-derived TGFBR3/TGF-beta RIII protein, expressed by Sf9 insect cells, with C-His labeled tag. The total length of TGFBR3/TGF-beta RIII Protein, Human (sf9, His) is 761 a.a., with molecular weight of ~88 kDa.

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Description

TGFBR3/TGF-beta RIII Protein is pivotal, binding to TGF-beta, indicating a potential role in capturing and presenting TGF-beta to signaling receptors. In gonadotrope cells, it acts as an inhibin A coreceptor, regulating FSH levels and impacting female fertility. Its interaction with DYNLT4 emphasizes diverse functional associations in cellular processes, suggesting a multifaceted role for TGFBR3 in cellular regulation and fertility control. TGFBR3/TGF-beta RIII Protein, Human (sf9, His) is the recombinant human-derived TGFBR3/TGF-beta RIII protein, expressed by Sf9 insect cells, with C-His labeled tag. The total length of TGFBR3/TGF-beta RIII Protein, Human (sf9, His) is 761 a.a., with molecular weight of ~88 kDa.
Background

The TGFBR3/TGF-beta RIII protein plays a pivotal role as it binds to TGF-beta, suggesting potential involvement in capturing and retaining TGF-beta for presentation to the signaling receptors, as inferred by similarity to related proteins. Particularly in gonadotrope cells, TGFBR3 acts as an inhibin A coreceptor, exerting regulatory control over follicle-stimulating hormone (FSH) levels and influencing female fertility, as indicated in relevant studies. Furthermore, TGFBR3 interacts with DYNLT4, underscoring its diverse functional associations in cellular processes.
Species

Human
Source

Sf9 insect cells
Tag

C-His
Accession

Q03167 (G21-G781)
Gene ID
Molecular Construction
N-term
TGFBR3 (G21-G781)
Accession # Q03167
His
C-term
Synonyms
TGFBR3; TGF-bRIII; TGFR-3; Transforming growth factor beta receptor III; Betaglycan
Molecular Weight

Approximately 88 kDa
Purity

Greater than 95% as determined by reducing SDS-PAGE.
Endotoxin Level

<1 EU/μg, determined by LAL method.
Documentation
Handling Instructions (2659 KB)

TGFBR3/TGF-beta RIII Protein, Human (sf9, His) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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